Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1983-02-07
1984-11-20
Kepplinger, Esther M.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 16, 424 21, 424 28, 604890, 604892, 604896, 604897, A01N 2526, A01N 2534
Patent
active
044838468
ABSTRACT:
The present invention provides new three-layered pharmaceutical film preparations which comprise one drug-storing middle layer composed of one or more (a) polyvinylpyrrolidone, (b) hydroxypropyl cellulose, (c) plasticizers and (d) organic acids, containing prostaglandin analogues, and two release-controlling layers on both sides of the said middle layer, composed of one or more (a) hydroxypropyl cellulose and (b) plasticizers, containing or not containing prostaglandin analogues, and which may release the drug at the desired concentration lastingly for an extended period of time, with great high biological availability, and can make this release "zero-order release", and further have improved the stability of the drug contained therein, and in which the form of the preparation is not retained at the administered site after administration.
REFERENCES:
patent: 3926188 (1975-12-01), Baker et al.
patent: 4180558 (1979-12-01), Goldberg et al.
patent: 4317447 (1982-03-01), Williams
patent: 4335097 (1982-06-01), David et al.
patent: 4359483 (1982-11-01), Kaetsu et al.
patent: 4451260 (1984-05-01), Mitra
Derwent, No. 47633v.
Derwent, No. 35619e.
Derwent, No. 43052w.
Chem. Abs.; 91: 112398w (Khristenko et al.).
Inaba Kohji
Koide Tatsushi
Sasatani Seiei
Foley Shawn P.
Kepplinger Esther M.
Ono Pharmaceutical Co. Ltd.
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