Long-lasting release nifedipine preparation

Details Long-lasting release nifedipine preparation Long-lasting release nifedipine preparation

1996-11-21

1999-01-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424482, 424474, A61K 932, A61K 936

Patent

active

058611738

ABSTRACT:
This invention provides a long-lasting release solid nifedipine preparation which exhibits clinically sufficient effect when administered once per day. A press coated tablet whose core and shell each contains nifedipine, the dissolution rate of nifedipine from said tablet being (a) in the dissolution test using a sinker according to method 2 of the dissolution test method as prescribed by the Pharmacopoeia of Japan, after 2 hours 10-40% after 4 hours 30-65% after 6 hours at least 55%, and (b) in the dissolution test according to the disintegration test method as prescribed by the Pharmacopoeia of Japan, after 3 hours 20-45% after 4 hours 30-65%.

REFERENCES:
patent: 4892741 (1990-01-01), Ohm et al.
patent: 4933186 (1990-06-01), Ohm et al.
patent: 4966772 (1990-10-01), Ohm et al.
English language abstract of JP 40-14446 (1984).
English language abstract of JP 04-11699 (1994).

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