Long-lasting multi-layered film preparation

Details Long-lasting multi-layered film preparation Long-lasting multi-layered film preparation

1981-10-19

1985-11-12

Kepplinger, Esther M.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 16, 424 21, 424 28, 514443, 514573, A01N 2526, A01N 2534

Patent

active

045527512

ABSTRACT:
The present invention provides multi-layered film preparations which comprise one or more water soluble polymer bases, one or more water insoluble polymer bases, one or more plasticizers and one or more prostaglandins, and optionally contain one or more organic acids, and they are composed of at least two drug release controlling layers and one or more drug storing layers. The multi-layered film preparations of the present invention are characterized by that the prostaglandin(s) containing therein exhibit the desired long-lasting release patterns at the concentration required for therapeutic purpose.

REFERENCES:
patent: 3926188 (1975-12-01), Baker et al.
patent: 4180558 (1979-12-01), Goldberg et al.
patent: 4265874 (1980-04-01), Bonsen et al.
patent: 4317447 (1982-03-01), Williams
patent: 4335097 (1982-06-01), David et al.
patent: 4483846 (1984-11-01), Koide et al.
Derwent 35619 E/18.
Derwent 37166 D/21.
Derwent 43052 W/16.
Derwent 47633 V/26.
Chem. Abs. 93:191993d, (1980).
Remington's Pharmaceutical Science, 15th Ed.; 1975, Ch. 91, Mack Pub. Co., Easton, Pa.

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