Long lasting composition of propafenone and quinidine for treatm

Details Long lasting composition of propafenone and quinidine for treatm Long lasting composition of propafenone and quinidine for treatm

1988-05-03

1990-09-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, A61K 920

Patent

active

049543474

ABSTRACT:
A pharmaceutical composition for the treatment of cardiac arrhythmia comprising an effective amount of propafenone in combination with a subtherapeutic amount of quinidine, such that the quinidine potentiates the elimination half-life of the propafenone.
The invention also comprises a method for treating patients with cardiac arrhythmia by means of administering said pharmaceutical composition.

REFERENCES:
patent: 4460605 (1984-07-01), Petrik et al.
patent: 4557934 (1985-10-01), Cooper et al.
patent: 4612320 (1986-09-01), Franke et al.
Connolly et al., "Clin. Efficacy & Electrophysiology of Oral Propafenone for Vent. Tachycardia", Am. J. Card., vol. 52, pp. 1208-1213, (Dec. 1983).
Siddoway et al., "Polymorphic Oxidative Metabolism of Propafenone in Man", Circulation 68, (Supp. III), p. 64, (Oct. 1983).
Otton et al., "Competitive Inhibition of Sparteine Oxidation in Human Liver . . . ", Life Sciences, vol. 34, pp. 73-80, (1984).
Leeman et al., "Single-Dose Quinidine Treatment Inhibits Metaprolol Oxidation in Extensive Metabolizers", Eur. J. Clin. Pharmocol., 29:739-741, (1986).
Klein et al., "Enhanced Antiarrhythmic Efficacy of Propafenone When Used in Combination with Procainamide or Quinidine", Am. Heart J., (Sep. 1987), pp. 551-558.

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