Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-11-27
1981-03-03
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
424246, 2601125R, 424263, 424274, 424244, 26032613R, 548336, A61K 3700, C07C10352, A01N 4384, C07D20918
Patent
active
042541077
ABSTRACT:
Novel peptides of the formula: ##STR1## wherein X is S or (CH.sub.2).sub.n and n is 0, 1 or 2, and R.sub.1 through R.sub.6 are various amino acid and other substituents; having long-lasting enkephalin agonist activity; useful in treating pain and in treating schizophrenia.
REFERENCES:
Hughes, J. et al., Nature 258, 577-579 (1975).
Restak, Sat. Rev., 3-5-77, pp. 7-11.
Snyder, C&EN, Nov. 28, 1977, 26-35.
Pert et al., Nature 269, 73-75, 1977.
Klee, "Endogenous Opiate Peptides," Peptides in Neurobiology, Plenun Press, N.Y., pp. 375-396 (1977).
C&EN, Aug. 16, 1976, pp. 18-19.
Heterocycles 9, No. 7, pp. 831-849.
Freidinger Roger M.
Veber Daniel F.
Merck & Co. , Inc.
Monaco Mario A.
Phillips Delbert R.
Speer Raymond M.
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