Long-lasting adhesive antifungal suppositories

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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Details

424281, 424DIG15, 514462, 514457, 514781, A61K 902, A61K 3171

Patent

active

045420203

ABSTRACT:
Antifungal suppositories are provided which preferably include nystatin as the antifungal agent, together with a hydrocolloid, such as sodium carboxymethylcellulose or hydroxypropylmethylcellulose and a low melting suppository base. The antifungal suppositories of the invention function by melting at body temperature to release the hydrocolloid and antifungal agent which adhere to the vaginal membrane so that a uniform distribution of antifungal agent is retained at the site of infection.

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Noro et al., Chem. Pharm. Bull. 30(8): 2900-2905 (1982) Studies on Pharmaceutical Drug Design for Suppositories I, Effect of Physico-Chemical Properties of Surfactants and Polymers on Emulsion-Type Bases.
P. D. R. 31th Ed. (1977) Baker et al., Medical Economics, Oradell, N.J., p. 1525, Squibb Mycostatin Vaginal Tablets (Nystatin Vaginal Tablets, U.S.P.) (for Vulvovaginal Candidiasis).
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