Long-chain prenyl diphosphate synthase

Details Long-chain prenyl diphosphate synthase Long-chain prenyl diphosphate synthase

1996-08-29

1998-09-15

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

4351721, C12N 910, C12N 1500

Patent

active

058077251

ABSTRACT:
The present invention discloses a mutated enzyme comprising a geranylgeranil diphosphate synthase having its origin in wild type Sulfolobus acidocaldarius wherein, at least one of phenylalanine at position 77, methionine at position 85, valine at position 99, tyrosine at position 101, phenylalanine at position 118, arginine at position 199 and aspartic acid at position 312 is substituted with another amino acid.

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Chen, et al., Protein Science, vol. 3, pp. 600-607, 1994.
Song, et al., Proc. Natl. Acad. Sci. USA, vol. 91, pp. 3044-3048, Apr. 1994.
Koyama, et al., Biochemistry, 33:42, pp. 12644-12648, 1994.

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