Long chain carboxylic acid maleimides

Details Long chain carboxylic acid maleimides Long chain carboxylic acid maleimides

1993-05-11

1994-11-01

Lilling, Herbert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548547, 548548, A61K 3750, C07K 1512, C07D207452

Patent

active

053609140

ABSTRACT:
Provided are novel superoxide dismutase derivatives represented by the following general formula (I) ##STR1## wherein [SOD] is a superoxide dismutase residue derived by removal of two mercapto groups, and W is a divalent long chain hydrocarbon residue which may optionally be interrupted by one or more groups each independently selected from the group consisting of an oxygen atom, a sulfur atom and a group of -N(R)- (R being a lower alkyl group). The SOD derivatives retain most of the enzymatic activities of unmodified SOD and have much longer plasma half-life than unmodified SOD. They are effective for treating various diseases caused by active oxygen species.
Also provided are chemical modifiers to prepare the above SOD derivatives.

REFERENCES:
patent: 3811830 (1974-05-01), DeMarco
patent: 4954637 (1990-09-01), Nitecki et al.
CA96(25):217629d, Gonzales et al Abstract of "An Quim, Ser A," 77(1) 158-160 (1981).
CA103(17):137660e, Moore et al Abstract of "Biochem Soc. Trans" 13(4) 690-1 (1985).
U.S. Patent Office "Patent Classification Definitions".

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