Long-chain .alpha.,.omega.-dicarboxylic acids and derivatives th

Details Long-chain .alpha.,.omega.-dicarboxylic acids and derivatives th Long-chain .alpha.,.omega.-dicarboxylic acids and derivatives th

1984-06-22

1987-08-25

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514519, 514528, 514529, 514533, 514547, 514558, 514559, 514560, 514616, 514623, 514624, 514625, 514626, 514627, 514628, 560 81, 560 82, 560127, 560154, 560171, 560190, 560192, 260546, 558439, 558442, 562459, 562468, 562488, 562489, 562498, 562506, 562509, 562565, 562571, 562582, 562590, 562594, 562595, 562596, A61K 3116, A61K 3120, A61K 31225, A61K 31275

Patent

active

046893440

ABSTRACT:
A novel class of compounds has been found to be effective in blocking cholesterol and neutral lipid synthesis in-vivo without adversely affecting energy metabolism, useful for the treatment of obesity, hyperlipidemia and maturity-onset diabetes. The active compounds have the general formula ##STR1## or in-vivo hydrolyzable functional derivatives of the carboxylic groups thereof,
wherein

REFERENCES:
patent: 2971915 (1961-02-01), Borsoff et al.
patent: 3678102 (1972-07-01), Isard et al.
patent: 3773946 (1973-11-01), Creger
patent: 3776951 (1973-12-01), Failey et al.
patent: 3930024 (1975-12-01), Creger
Schisla; et al; J. Org. Chem., 35 (1970), pp. 3224-3230.
Beilstein; vol. 2; 2nd Supp., (1942), p. 627; Springes-Verlag, Berlin.
Beilstein; vol. 2; 4th Supp., (1976), pp. 2168, 2169, 2174, 2180, 2181, 2191, 2192, Springes-Verlag, Berlin.
Bouvier, et al.; Bull. Soc. Chim. Fr. (1975), No. 9-10, pp. 2195-2201.

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