Long-acting theophylline in medicinal form

Details Long-acting theophylline in medicinal form Long-acting theophylline in medicinal form

1983-05-03

1985-04-23

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514617, 514621, A61K 3152

Patent

active

045129940

ABSTRACT:
Long-acting forms of theophylline for use in treating asthma comprise theophylline associated with a compound of the substituted cinnamamide type of the general formula ##STR1## wherein R is hydrogen, a hologen or an acetyl radical; R.sub.1 is hydrogen or the methyl radical; R.sub.2 is ##STR2## wherein R.sub.3 is hydrogen or the methyl radical; or R.sub.1 and R.sub.2 together with the adjacent nitrogen tom form the 2,2-dimethyl-3-oxazolidinyl group.

REFERENCES:
patent: 3780102 (1973-12-01), Bayssat et al.
Cutting's Handbook of Pharmacology, 4th Ed., 1967, pp. 294-296.
Chemical Abstracts vol. 92, Jun. 23, 1980, No. 25 (92: 208747f Inhibition by Idrocilamide of the Disposition of Caffeine)(J. L. Brazier) 1-Pharmacodynamics.
European Journal of Medicinal Chemistry (Chimica Therapeutica) vol. IX, Sep.-Oct. 1974, No. 5.

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