Long acting preparation of cefalexin for effective treatments of

Details Long acting preparation of cefalexin for effective treatments of Long acting preparation of cefalexin for effective treatments of

1977-05-27

1981-02-10

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Lymphokine

424246, A61K 3178, A61K 3154

Patent

active

042501660

ABSTRACT:
A cefalexin preparation coated with a coating layer the solubility of which layer is pH-dependent and dissolves in the upper intestine is preferably administered concurrently with a normal (plain, quick-releasing) cefalexin. The coated preparation is preferably coated, in the particle form and when administered orally, exists in the particle form in the stomach. Preferably, the coating layer is made from a coating material having a dissolution pH of from 5.5 to 6.5, and the ratio in terms of potency of the coated cefalexin to the normal cefalexin is between 15:85 and 60:40. The coated cefalexin and the normal cefalexin can be formulated in a pharmaceutical preparation preferably in a unit-dosage form, e.g., capsules, tablets or particles or in strip-packages.

REFERENCES:
patent: 3078216 (1963-02-01), Grief
Derwent 02444U, Abstracting, DT-OS 2135073, published Oct. 16, 1972.
Derwent 47983R-AB, Abstracting DT-1814669-Q, published Jul. 2, 1970.
Austria Codex 1974/1975, 1975, pp. 130 & 365.
Derwent #1643T, Abstracting DT 2030501, published Dec. 30, 1971.
Derwent 65478W/39, Abstracting US 3906086, published Sep. 15, 1975.
Derwent 762040-B, Abstracting DT 2325410Q, published May 18, 1973.
Derwent 43846T, Abstracting BE-777158Q, published Jun. 22, 1972.
Derwent 81270V, Abstracting DT-2421273, published Nov. 14, 1974.
Derwent S9394S, Abstracting FR-2059978-Q, published Jun. 11, 1971.

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