Long-acting polypeptides and methods of producing same

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S009900, C530S351000, C530S398000, C530S402000

Reexamination Certificate

active

08048849

ABSTRACT:
A polypeptide and polynucleotides encoding same comprising one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to an amino terminus of a cytokine and two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a carboxy terminus of a cytokine are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.

REFERENCES:
patent: 5177193 (1993-01-01), Boime
patent: 5759818 (1998-06-01), Boime
patent: 5792460 (1998-08-01), Boime
patent: 6238890 (2001-05-01), Boime et al.
patent: 6514729 (2003-02-01), Bentzien
patent: 7094566 (2006-08-01), Medlock et al.
patent: 7141547 (2006-11-01), Rosen et al.
patent: 7371373 (2008-05-01), Shirley et al.
patent: 7553940 (2009-06-01), Fares et al.
patent: 7553941 (2009-06-01), Fares et al.
patent: 2003/0216313 (2003-11-01), Lustbader et al.
patent: 2007/0184530 (2007-08-01), Fares et al.
patent: WO 2005/080544 (2004-03-01), None
Fares et al. Designing a long-acting human growth hormone (hGH) by fusing the carboxy-terminal peptide of human chorionic gonadotropin B-subunit to the coding sequence of hGH. Endocrinology, vol. 151(9):4410-4417 (Sep. 2010).
Weiss et al. Noncompliance in Neurologic Patients. Current Treatment Options in Neurology 7:419-425 (2005).
Furuhashi, M. et al; ‘Fusing the Carboxy-terminal Peptide of the Chorionic Gonadotropin (CG) β-Subunit to the Common a-Subunit: Retention of O-linked Glycosylation and Enhanced in vivo Bioactivity of Chimeric Human CG’ , Molecular Endocrinology, 1995, vol. 9, No. 1, pp. 54-63.
Furuhashi, M. et al, ‘Processing of O-linked Glycosylation in the Chimera Consisting of a-Subunit and Carboxyl-terminal Peptide of the Human Chorionic Gonadotropin β-Subunit is affected by Dimer Formation with Follicle-stimulating Hormone α-Subunit’, Endocrine Journal 2004, vol. 51, No. 1, pp. 53-59.
Schein, Catherine H. The shape of the messenger: using protein structure information to design novel cytokine-based therapeutics. ABSTRACT; Current Pharmaceutical Design, vol. 8/No. 24, pp. 2113-2129 (2002).
Amirizahdeh et al. “Transient and stable expression of biologically active recombinant B-domain-deleted human factor VIII in mammalian cells” Journal of Sciences Islamic Republic of Iran; 16(2):103-112. Spring, 2005.
Boissel et al. “Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure” The Journal of Biological Chemistry,268, 15983-15993, Jul. 25, 1993.
Fares et al. “Growth Hormone (GH) Retardation of Muscle Damage due to Immobilization in Old Rats Possible Intervention with a New Long-Acting Recombinant GH” Ann N Y Acad Sci. 786:430-43. Jun. 15, 1996.
Houdebine et al. “The methods to generate transgenic animals and to control transgene expression” Journal of Biotechnology vol. 98, Issues 2-3, pp. 145-160, Sep. 25, 2002.
Ngo et al. “Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox” The protein folding problem and tertiary structure prediction. pp. 433-440 and 492-495. (1994).
Phillips et al. “The challenge of gene therapy and DNA delivery” Journal of Pharmacy and Pharmacology vol. 53, Issue 9, pp. 1169-1174, Sep. 2001.
Unalp et al. “Factor VII deficiency associated with Valproate treatment” Pediatrics International vol. 50, Issue 3, pp. 403-405, Jun. 2008.
Wells. “Additivity of mutational effects in proteins” Biochemistry, 29 (37), pp. 8509-8517. (1990).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Long-acting polypeptides and methods of producing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Long-acting polypeptides and methods of producing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Long-acting polypeptides and methods of producing same will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4277698

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.