Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Reexamination Certificate
2007-02-01
2009-06-30
Allen, Marianne P (Department: 1647)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
C514S002600, C435S069100
Reexamination Certificate
active
07553941
ABSTRACT:
A polypeptide and polynucleotides encoding same comprising at least two carboxy-terminal peptides (CTP) of chorionic gonadotrophin attached to a peptide-of-interest are disclosed. Pharmaceutical compositions comprising the polypeptide and polynucleotides of the invention and methods of using same are also disclosed.
REFERENCES:
patent: 3791932 (1974-02-01), Schuurs et al.
patent: 3839153 (1974-10-01), Schuurs et al.
patent: 3850578 (1974-11-01), NcConnell
patent: 3850752 (1974-11-01), Schuurs et al.
patent: 3853987 (1974-12-01), Dreyer
patent: 3867517 (1975-02-01), Ling
patent: 3879262 (1975-04-01), Schuurs et al.
patent: 3901654 (1975-08-01), Gross
patent: 3935074 (1976-01-01), Rubinstein et al.
patent: 3984533 (1976-10-01), Uzgiris
patent: 3996345 (1976-12-01), Ullman et al.
patent: 4034074 (1977-07-01), Miles
patent: 4098876 (1978-07-01), Piasio et al.
patent: 4666828 (1987-05-01), Gusella
patent: 4683202 (1987-07-01), Mullis
patent: 4801531 (1989-01-01), Frossard
patent: 4873316 (1989-10-01), Meade et al.
patent: 4879219 (1989-11-01), Wands et al.
patent: 5011771 (1991-04-01), Bellet et al.
patent: 5192659 (1993-03-01), Simons
patent: 5272057 (1993-12-01), Smulson et al.
patent: 5281521 (1994-01-01), Trojanowski et al.
patent: 5464764 (1995-11-01), Capecchi et al.
patent: 5487992 (1996-01-01), Capecchi et al.
patent: 5759818 (1998-06-01), Boime
patent: 5932447 (1999-08-01), Siegall
patent: 6238890 (2001-05-01), Boime et al.
patent: 7094566 (2006-08-01), Medlock et al.
patent: 264166 (1966-08-01), None
Bitter et al., “Expression and secretion vectors for yeast”(1987) Methods in Enzymol. 153:516-544.
Brisson et al. (1984) Nature 310:511-514.
Takamatsu et al. “Expression of bacterial chloramphenicol acetyltransferase gene in tobacco plants mediated by TMV-RNA.”(1987) EMBO J. 6:307-311.
Coruzzi et al. “Tissue-specific and light-regulated expression of a pea nuclear gene encoding the small subunit of ribulose-1,5-bisphosphate carboxylase” (1984) EMBO J. 3:1671-1680.
Brogli et al, (1984) Science 224:838-843.
Gurley et al. “Upstream sequences required for efficient expression of a soybean heat shock gene.” (1986) Mol. Cell. Biol. 6:559-565.
Pinkert et al., “An albumin enhancer located 10 kb upstream functions along with its promoter to direct efficient, liver-specific expression in transgenic mice.” (1987) Genes Dev. 1:268-277.
Calame et al., “Transcriptional controlling elements in the immunoglobulin and T cell receptor loci.” (1988) Adv. Immunol. 43:235-275.
Winoto et al., “A novel, inducible and T cell-specific enhancer located at the 3' end of the T cell receptor alpha locus.” (1989) EMBO J. 8:729-733.
Banerji et al. “A lymphocyte-specific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes.” (1983) Cell 33729-740.
Byrne et al. “Multiplex gene regulation: a two-tiered approach to transgene regulation in transgenic mice.” (1989) Proc. Natl. Acad. Sci. USA 86:5473-5477.
Edlund et al. (1985) Science 230:912-916.
Srour, M.A., et al., 2003. Thromb. Haemost. 90: 398-405.
Studier et al., Methods in Enzymol. 185:60-89 (1990).
Bohl et al., “Improvement of erythropoiesis in beta-thalassemic mice by continuous erythropoietin delivery from muscle.” Blood. 2000; 95:2793-2798.
Gao et al., “Erythropoietin gene therapy leads to autoimmune anemia in macaques” Blood, 2004, vol. 103, No. 9.
Lippin et al “Human erythropoietin gene therapy for patients with chronic renal failure.” 2005, 106, No. 7.
Booth et al., “The use of a ‘universal’ yeast expression vector to produce an antigenic protein ofMycobacterium leprae. ” Immunol. Lett. 19:65-70 (1988).
Gardella et al., “Expression of human parathyroid hormone-(1-84) inEscherichia colias a factor X-cleavable fusion protein.” J. Biol. Chem. 265:15854-15859 (1990).
Goodson, inMedical Applications of Controlled Release, supra, vol. 2, pp. 115-138 (1984).
Fingl, et al., (1975) “The Pharmacological Basis of Therapeutics”, Ch. 1 p. 1.
Hammerling U. et al “In vitro bioassay for human erythropoietin based on proliferative stimulation of an erythroid cell line and analysis of carbohydrate-dependent microheterogeneity” Journal of Pharm. Biomed. Analysis 14(11): 1455-1469 (1996).
Dong et al., Biochemical and Biophysical Research Communications, vol. 339, Issue 1, Jan. 6, 2006, pp. 380-385.
Fares Fuad
Fima Udi Eyal
Allen Marianne P
Cohen Mark S.
DeBerry Regina M
Modigene Inc
Pearl Cohen Zedek Latzer LLP
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