Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1979-04-18
1980-12-02
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, A61K 3700, C07C10352
Patent
active
042371198
ABSTRACT:
The use of long-acting oxytocin analogs, characterized chemically by replacement of the disulfide bridge by a thioether bridge, in safely inducing labor in mammals is disclosed. Of particular importance in the use of these compounds is the safety factor, that is, the absence of uterine tetany, dangerous to both mother and fetus, at dosage levels required for induction of complete labor. Induction of complete labor can be accomplished with one or, at most, two single injections.
REFERENCES:
Torchiana, et al., Experimentia (1964) 24, pp. 570-571.
Kobayashi, et al., Bull. Chem. Soc. Japan 42, pp. 3491-3495 (1969).
Berde, Molecular Aspects 1968 pp. 53-65.
Barth Tomislav
Cort Joseph H.
Jost Karel
Veznik Zdenek
Ceskoslovenska akademie ved
Phillips Delbert R.
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