Long-acting galenical formulation for GRF peptides

Details Long-acting galenical formulation for GRF peptides Long-acting galenical formulation for GRF peptides

1996-06-14

1998-10-06

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 2, 514 13, 514 14, 514 15, 514 16, 514 17, 514 18, 514 19, 514 10, 514 11, 514 12, 514 21, 514 8, 424422, 424468, 530324, 530325, 530326, 530327, 530328, 530329, 530330, 530399, A01N 3718, A61K 3800, A01J 2100, C07K 500

Patent

active

058176276

ABSTRACT:
The present invention relates to a long-acting galenical formulation of GRF peptides, pro-GRF and/or analogs thereof which comprises about 1 to about 100 mg of a GRF peptide, fragment or analog thereof pressed from about 1 to about 100 kg/mm.sup.2 in a tablet for parenteral administration, whereby these GRF peptides are released as the tablet is eroded.

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Mariette, et al., Stereocopolymers for Parenteral Sustained-Release Peptides: Release of . . . , J. Controlled Release, vol. 28, No. 1-3, pp. 297-298, 1993.
Auzerie, et al., Growth Hormone Releasing Hormone Treatment . . . , Archives de Pediatrie, vol. 2 No. 4, pp. 365-372, 1995.

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