Long acting diltiazem formulation

Details Long acting diltiazem formulation Long acting diltiazem formulation

1989-08-25

1991-03-19

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424475, 424480, A61K 932

Patent

active

050009621

ABSTRACT:
A long acting diltiazem formulation is disclosed that comprises more than 35 percent by weight of a swellable hydrophilic polymer.
Release rate is also controlled by the application of diffusion controlled membrane to the matrix tablet containing swellable hydrophilic polymers. The diffusion rate through the membrane depends upon the composition or ratio of hydrophilic to hydrophobic coating agent.

REFERENCES:
patent: 4389393 (1983-06-01), Schor et al.
patent: 4411933 (1983-10-01), Samejima et al.
patent: 4443497 (1984-04-01), Samejima et al.
patent: 4462982 (1984-07-01), Samejima et al.
patent: 4542042 (1985-09-01), Samejima et al.
patent: 4721619 (1988-01-01), Panoz et al.
patent: 4784858 (1988-11-01), Ventouras
patent: 4804540 (1989-02-01), Nugent et al.

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