Long acting calcium channel blocker composition

Details Long acting calcium channel blocker composition Long acting calcium channel blocker composition

1991-09-13

1993-05-11

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424497, 514356, A61K 916

Patent

active

052099334

ABSTRACT:
There is disclosed an improved long acting sustained release pharmaceutical composition for dihydropyridine calcium channel blockers wherein the calcium channel blocker and a pH-dependent binder, which are intimately admixed in essentially spherically shaped non-rugose particles of up to 1.2 mm in diameter, are provided with a coating to obtain slow, sustained release of a safe, therapeutically effective amount of the calcium channel blocker over a period of at least about 24 hours. Thus, the improved pharmaceutical composition for a dihydropyridine calcium channel blockers is suitable for once daily administration.

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patent: 4765990 (1988-08-01), Sugimoto et al.
patent: 4816264 (1989-03-01), Phillips
patent: 4857312 (1989-08-01), Hegasy
patent: 4859665 (1989-08-01), Garthoff
patent: 4940556 (1990-07-01), MacFarlane
patent: 4970081 (1990-11-01), Frisbee

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