Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1987-08-26
1990-08-14
Sneed, H. M. S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
552638, C07J 900, A61K 3156
Patent
active
049487906
ABSTRACT:
Long-acting androgenic compositions comprising C.sub.4 -C.sub.6 cycloalkyl carboxylic acids of testosterone and a pharmaceutically acceptable carrier medium. The ester can be dissolved in an acceptable oily medium or suspended in an aqueous medium in the form of micronised particles or in the form of milled particles.
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Bischoff et al., J. Biol. Chem. 189:729-738 (1951) "Enzymatic Hydrolysis of Steroid Hormone Esters by Blood Serum".
Matlin S. A. et al., Chem. Abs., vol. 107 #33296 "Long Acting Androgans" (1987).
Bundgaard H. "Design of Prodrugs" in `Design of Prodrugs` Bundgaard H. ed.; Elsevier N.Y. (1985), pp. 2-4.
Ott et al.; J. Clin. Endocrinol. Metab. 12, 15-27 (1952); Testosterone -Cyclo-Pentylpropionate: A New Long-Lasting Androgen.
Gould et al.; J. Am. Chem. Soc. 79 4472-4475 (1957); Long-Acting Testosteron Esters. Some Consideration on Their Biological Utilization.
Weinbauer et al.; Acta Endocrinologica (COPENH) 1986, 113: 128-132; New Injectable Testosterone Ester Maintains Serum Testosterone of Castrated Monkeys in the Normal Range for Four Months.
Archer Sydney
Bialy Gabriel
Blye Richard P.
Crabbe, deceased Pierre
Crabbe, executor by Lucie
Saba James A.
Sneed H. M. S.
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