Loloatin derivatives and analogs

Details Loloatin derivatives and analogs Loloatin derivatives and analogs

1996-10-31

1999-10-05

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, 530328, A61K 3826

Patent

active

059624078

ABSTRACT:
Several cyclic decapeptides having antibiotic activity are disclosed. The decapeptides are active against both gram positive and gram negative bacteria.

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Gerard, et al, Loloatin B, A cyclic Decapeptide Antibibiotic Produced in Culture by a Tropical Marine Bacterium, Tetrahedron Letters, vol. 37, No. 40, pp. 7201-7204, 1996.
Edmond et al, Vancomycin-Resistant Enterococcus faecium Bacteremia: Risk Factors for Infection Clinical Infectious Diseases, vol. 20, 1126-33, 1995.
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Okamoto et al., "Studies of Peptide Antibiotics. XXXIV Syntheses of Tyrocidine A and Its Analogs Containing Glycine," Bulletin of the Chemical Society of Japan, 50(1):231-236, 1977.
Budavari et al.(eds.)., "The Merck Index ," 11.sup.th edition, Merck and Co., Rahway, N.J., 1989, p. 712, compound No. 4438.
Budavari et al.(eds.)., "The Merck Index ," th.sup.11 edition, Merck and Co., Rahway, N.J., 1989, p. 712, compound No. 4439.
Rollin D. Hotchkiss, "Gramicidin, Tyrocidine, and Tyrothricin," Advances in Enzymology and Related Subjects, 4:153-199, 1944.
N. Kosui et al., "Studies of Peptide Antibiotics, XLI. Synthesis of 6-L-Valine-Tyrocidine A and 7-L-Ornithine-Tyrocidine A" Int. J. Peptide Protein Res., 18, 127-134, 1981.

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