Locus control subregions conferring integration-site independent

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

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4351721, 4351723, C12Q 168, C12N 1563, C12N 1564, C12N 1590

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active

061106666

ABSTRACT:
The invention encompasses a locus control subregion that possesses chromatin opening domain activity, the activity conferring reproducible activation of tissue-specific expression on a linked transgene to a non-physiological level when the transgene is integrated in single copy in the genome of a host cell.

REFERENCES:
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