Surgery – Liquid medicament atomizer or sprayer
Patent
1994-10-28
1996-04-16
Lewis, Aaron J.
Surgery
Liquid medicament atomizer or sprayer
12820423, 12820523, A61M 1100
Patent
active
055072771
ABSTRACT:
A method of controlling access to a drug in an aerosol drug delivery device by an electronic lock and key means is disclosed. Access is limited to the intended user by providing the intended user with a uniquely coded, machine readable key means that matches the unique code of the lock means. Contacting matching lock and key means signals a controlling means to allow use of the device. Specifically, the method is applied to a method of pain control provided by the intrapulmonary delivery of a pharmaceutically active pain relief formulation. The formulation is automatically released from a hand-held, self-contained, portable device comprised of a means for automatically releasing a measured amount of drug into the inspiratory flow path of a patient in response to information obtained from a means for measuring and separately determining inspiratory flow rate and inspiratory volume of a patient. Reproducible dosing is obtained by providing for automatic release in response to a separately measured inspiratory rate and inspiratory volume. To obtain repeatability in dosing the narcotic formulation is repeatedly released at the same measured (1) inspiratory flow rate and (2) inspiratory volume. To maximize the efficiency of the delivery the narcotic formulation is released at (1) a measured inspiratory flow rate in the range of from about 0.10 to about 2.0 liters/second and (2) a measured inspiratory volume in the range of about 0.15 to about 0.8 liters. Abuse of narcotic formulations is avoided by providing a tamper-resistant device which includes a variety of security features including an electronic lock and key means and a pre-programmed microprocessor designed to avoid overdosing.
REFERENCES:
patent: 3812854 (1974-05-01), Michaels et al.
patent: 3991304 (1976-11-01), Hillsman
patent: 4604847 (1986-08-01), Moulding, Jr. et al.
patent: 4686231 (1987-08-01), Bender et al.
patent: 4934358 (1990-06-01), Nilsson et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5215079 (1993-06-01), Fine et al.
patent: 5261601 (1993-11-01), Ross et al.
patent: 5284133 (1994-02-01), Burns et al.
patent: 5293865 (1994-03-01), Altner et al.
patent: 5363842 (1994-11-01), Mishelevich et al.
Camp, J. P., "Patient-Controlled Analgesia", 1991, AFP Clinical Pharmacology, 44:2145-2150.
Chrusbasik, H. et al., "Absorption and bioavailability of nebulized morphine", 1988, Br. F. Anaesth. 61:228-230.
Gourlay, G. K., "Fentanyl Blood Concentration-"Analgesic Response Relationship in the Treatment of Postoperative Pain", 1988, Anesth. Analg. 67:329-337.
Higgins, M. J. et al., 1991, "Inhaled nebulized fentanyl for postoperative analgesia", 46:973-976.
Jaffe, A. B. et al., 1989, "Rats self-administer sufentanil in aerosol form", Psychopharmacology, 99:289-293.
Lehman, K. A., 1991, "Transdermal fentanyl for the treatment of pain after major urological operations", Eur. J. Clin. Pharmacol. 41:17-21.
Mather, L. E., "Pharmacokinetics and patient-controlled analgesia(*)", 1992, Acta Anaesthesiologica Belgica, 43:5-20.
Miller, R., "Anesthesia Second Edition", 1986, Churchill Livingstone, 1:762.
Newman, S. P. et al., "Deposition of pressurized aerosols in the human respiratory tract", 1981, Thorax, 36:52-55.
Newman, S. P. et al., "How should a pressurized .beta.-adrenergic bronchodilator be inhaled'", 1981, Eur. J. Respir. Dis. 62:3-21.
Newman, S. P. et al., "Deposition of pressurized suspension aerosols inhaled through extension devices", 1981, Am. Rev. Respir. Dis. 124:317-320.
Newman, S. P., "Deposition and Effects of Inhalation Aerosols," 1983.
Rapp, R. P. et al., "Patient-controlled analgesia: a review of effectiveness of therapy and an evaluation of currently available devices," 1989, DICP, The Annals of Pharmacotherapy 23:899-904.
Rosenberg, M., "Patient-Controlled Analgesia", 1992, J. Oral Maxillofac. Surg. 50:386-389.
Rowbotham, D. J., "A disposable device for patient-controlled analgesia with fentanyl", 1989, Anaesthesia, 44:922-924.
Ryder, E., "Ths history of patient-controlled analgesia", 1991, Journal of Intravenous Nursing, 14(6):372-381.
Shade, P., "Patient-controlled analgesia: can client education improve outcomes'", 1992, Journal of Advanced Nursing, 17:408-413.
Smythe, M., "Patient-controlled analgesia:a review", 1992, Pharmacotherapy, 99:289-293.
Stanley, T. H., "The history and development of the fentanyl series", 1992, Journal of Pain and Symptom Management, 7(Suppl.):S3-7.
Worsley, M. H. et al., "Inhaled fentanyl as a method of analgesia", Anaesthesia, 45:449-451 .
"How Should A Pressurized .beta.-Adreneregic Bronchodilator Be Inhaled?", Newman et al., Eur. J. Respir Dis. (1981) 62, 3-21.
Johansson Eric T.
Lloyd Lester J.
Rubsamen Reid M.
Aradigm Corporation
Bozicevic Karl
Lewis Aaron J.
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