Locked nucleic acid hybrids and methods of use

Details Locked nucleic acid hybrids and methods of use Locked nucleic acid hybrids and methods of use

2005-12-20

2005-12-20

Ketter, James (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S183000, C435S252300, C435S325000, C435S419000, C530S501000

Reexamination Certificate

active

06977295

ABSTRACT:
The invention relates to methods for inhibiting, cloning, modifying or labelling an endogenous DNA sequence using compositions comprising recombinases in combination with exogenous polynucleotides containing “anchoring” or “locking” sequences. The anchoring sequences serve to stabilize structures formed by the exogenous polynucleotides and the endogenous DNA. The stabilized structure thus can either serve to regulate gene transcription or replication, or can allow the endogenous sequences to be labelled or pulled out, i.e. cloned, or modified.

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