Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...
Patent
1989-01-24
1990-03-20
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Radical -xh acid, or anhydride, acid halide or salt thereof...
A61K 31195
Patent
active
049102257
ABSTRACT:
This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient.
An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type.
The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.
REFERENCES:
patent: 4045576 (1977-08-01), Welstead et al.
patent: 4126635 (1978-11-01), Welstead et al.
patent: 4568695 (1986-02-01), Moran et al.
patent: 4683242 (1987-07-01), Poser
Walsh et al., Journal of Medicinal Chemistry, 1989, vol. 27, No. 11, pp. 1379-1388.
Chem. Abst. 107-(1987)-211870z.
Kuribayashi Yoshikazu
Ogawa Takahiro
Ohtori Akira
Ushio Kazumichi
A. H. Robins Company Incorporated
Friedman Stanley J.
Senju Pharmaceutical Co. Ltd.
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