Localized oligonucleotide therapy

Details Localized oligonucleotide therapy Localized oligonucleotide therapy

1995-01-06

1997-01-14

Campell, Bruce R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

424426, 424486, 536 245, 604 52, 604 53, 935 44, 935 52, A61K 4800

Patent

active

055939740

ABSTRACT:
Disclosed is a method for localized application of antisense oligonucleotides, which has been found to be effective in inhibiting expression and translation of a variety of genes. The method utilizes antisense oligonucleotides which are specific for the mRNA transcribed from the gene of interest. The antisense oligonucleotides are applied directly to the desired locus of the cells to be treated, where they hybridize with the mRNA and inhibit expression of the gene. Devices for localized antisense application and methods for making them also are described.

REFERENCES:
patent: 3797485 (1974-03-01), Urguhart
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4898732 (1990-02-01), Fernandez
patent: 5098890 (1992-03-01), Gewirtz et al.
patent: 5171217 (1992-12-01), March et al.
CF Bennett (1996) Science 271:434.
K. Morikawa et al (1987) Cancer Research 47:37-41.
P Westermann et al (1989) Biomed Biochem Acta 48:85--93.
CA Stein et al (1993) Science 261:1004-1012.
RWeiss (1991) Science News 139:108-109.
Bennett et al (1994) J Clin Investigation 93:820-828.
Abe et al (1994) Biochem Biophys Res Commun. 198:16-24.
Anderson (1992) Cardiovasc. Pathol. 1:263-278.
EG Nabel et al (1990) Science 249:1285-1288.
Agrawal et. al. 1988, PNAS 85:7079-7083.
Jaskulski et al. 1988, Science 240:1544-1546.
Woolf et. al. 1990, NAR 18(7):1763-1769.
Sourin et al. 1988, PNAS 85: 7448-7451.
Applied Biosystems, User Bulletin No. 49, 1988.
JF Milligan et al (1993) J Med. Chem 36:1923-1937.
Dilley et al., Atheroscierosis, 63 (1987) pp. 99-107.
Libby et al., PDGF and Human Atheroma, 118 No. 23 (1988) pp. 1493-1498.
Schwartz et al., Cir Res 58:427-444, 1986.
Kuro et al., Jour. Bio Chem. vol. 264, No. 31 (1989) 18727-18275.
Clowes et al., Jour. Cell Bio. 107:1939-1945 (1988).
Nobuyoshi et al., JACC vol. 17, No. 2. 433--439 (1991).
Dilley et al., Arch Surg. vol. 123:691-696 (1988).
Schwartz et al., Hum Pathol 18:240-247 (1987).
Thompson et al., Nature 319:374-380 (1986).
Luscher et al., Genes & Development 4:2235-2241 (1990).
Reilly et al., Jour. Cell. Phys. 131:149-157 (1987).
Nature 265:625-626 (1977).
Guyton et al., Cir. Res. 46:625-634 (1980).
Fritze et al., Jour. Cell Bio. 100:1041-1049 (1985).
Katsuragawa et al., Inst. Basic Med Sci. 610-616.
Kawamoto et al., Jour. Cell Bio. 112:915-924 (1991).
Kawamoto et al., Jour. Bio. Chem. 262:7282-7288 (1987).
Fager et al., In Vitro Cell. Devel. Bio. 25:511-520 (1989).
Weir et al., Supp. Cir. 82:1990 574.
Shohet et al., Proc. Natl. Acad. Sci. 86:7726-7730 (1989).
Reilly Jour. Cell. Phys. 142:342-351.
Klein et al., Prog. Card. Dis.32:365-382 (1990).
C. F. Reilly et al., J. Biol. Chem. 264(12) 6990-6995 (1989).
T. J. Gonda et al., The EMBO Journal, 4(8) 2003-2008 (1985).
M. Simons et al., Cir. Res., 69(2): 530-539 (1991).
G. Anfossi et al., Proc. Nat'l Acad. Sci USA, 86: 3379-3383 (1989).
Brown et al., "Expression of the C-myb Proto-oncogene in Bovine Vascular Smooth Muscle Cells," J. Biol. Chem., 267:4625-30 (1992).
Pickering et al., "Proliferation of Human Vascular Smooth Muscle Cells Using Antisense Oligonucleotides to PCNA," J. Am. Coll. Cardiol., 19:165A (1992).
Rothenberg et al., "Oligodeoxynucleotides as Anti-Sense Inhibitors of Gene Expression: Therapeutic Implications," J. National Cancer Institute, 81:1539-1545 (1989).
Saez et al., "Human Nonmuscle Myosin Heavy Chain mRNA: Generation of Diversity Through Alternative Polyadenylation," PNAS, 87:1164-1168 (1990).
Shaw et al., "Modified Deoxyoligonucleotides Stable to Exonuclease Degradaton in Serum," Nucleic Acids Research, 19:747-750 (1991).
Simons et al., "Antisense Nomuscle Myosin Heavy Chain and c-MYB Oligonucleotides Suppress Smoth Muscle Cell Proliferation in Vitro," Circulation Research, 70:835-843 (1992).
Uhlmann et al., "Antisense Oligonucleotides: A New Therapeutic Principal," Chemical Reviews, 90:543-584 (1990).

Affiliated with

Also associated with

Rating

Localized oligonucleotide therapy does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Localized oligonucleotide therapy, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Localized oligonucleotide therapy will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1388246