Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1993-08-20
1994-11-22
Stone, Jacqueline
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
424450, 530380, 530810, 530812, A61K 3702, A61K 9127, A61K 9133, C07K 702
Patent
active
053669584
ABSTRACT:
This invention encompasses new and substantially improved methods and compositions for delivery of therapeutic agents to specifically chosen body sites. Conjugation of fibronectin to bioactive agents or to lipids or to liposomes which entrap the bioactive agents permits immobilization of the bioactive agent when administered at collagen-, heparin-, hyaluronic acid-, fibrin/fibrinogen-, or ganglioside-rich sites. Covalent conjugation is achieved by two methods: (1) the enzymatically catalyzed cross-linkage of fibronectin to an amine containing compound, and (2) by a modified NHS method which permits formation of peptide bonds between fibronectin and lipid compounds.
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Carpenter-Green Sharon S.
Fountain Michael W.
Lenk Robert P.
Weiner Alan L.
Bloom Allen
Feeney Joanne Longo
Stone Jacqueline
The Liposome Company Inc.
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