Localization of cancerous tissue by monitoring infrared fluoresc

Details Localization of cancerous tissue by monitoring infrared fluoresc Localization of cancerous tissue by monitoring infrared fluoresc

1983-06-02

1985-09-17

Cohen, Lee S.

Surgery

Truss

Pad

424 9, A61B 600

Patent

active

045414386

ABSTRACT:
An improved apparatus and method for optically localizing cancer lesions occluded beneath healthy tissue layers. A porphyrin tumor-specific marker is injected into a patient. After several days the healthy tissue has released the tumor-specific marker but the cancerous tissue has retained the tumor-specific marker. A long wavelength red excitation light illuminates an area of tissue and excites the porphyrin tumor-specific marker to fluorescence. An optical detection means monitors fluorescent emissions in the near infrared band and locates the source of the emissions.

REFERENCES:
patent: 4236526 (1980-12-01), Richard
patent: 4266549 (1981-05-01), Kimura
patent: 4336809 (1982-06-01), Clark
Kinsey et al., "Endoscopic System . . . Fluorescence", Rev. Sci. Inst. 51 (10), 1403-1406, Oct. 1980.
Dougherty et al., "Photoradiation Therapy . . . Tumors", Cancer Research, vol. 38, pp. 2628-2635, Aug. 1978.
Doiron et al., "Fluorescence Bronchoscopy . . . Cancer", Chest, 76:1, pp. 27-32, Jul. 1979.

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