Localization of a therapeutic agent in a cell in vitro

Details Localization of a therapeutic agent in a cell in vitro Localization of a therapeutic agent in a cell in vitro

1994-10-14

1998-12-29

Elliott, George C.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4353201, 536 245, C12N 1586, C12N 1511, C12N 500, C12N 510

Patent

active

058540385

ABSTRACT:
Method for enhancing the effect of a viral therapeutic agent in a cell in vitro on the viral target by tethering a localization signal to the therapeutic agent so that the agent localizes with the viral target in a cellular or viral compartment of the cell.

REFERENCES:
M.I. Johnston et al. (1993) Science 260:1286-1293.
D. Cournoyer et al. (1993) Annu. Rev. Immunol. 11:297-329.
M.B. Feinberg et al. (1992) Aids Res. and Human Retrovir. 8(6):1013-1022.
B. Dropulic et al. (1992) J. Virol. 66(3):1432-1441.
J.O. Ojwang et al. (1992) Proc. Natl. Acad. Sci. USA 89:10802-10806.
J.A. Zaia et al. (1992) Annals of NY Acad. Sci. 660:95-106.
R. Tellier et al (1985) Nature 318:414.
M.C. Poznansky et al (1991) Int. Conf. Aids 7(2): p. 25 (Abstract No. W.A. 13).
M. Weerasinghe et al (1991) J. Virology 65(10):5531-5534.
Sarver et al., 247 Science 1222, 1990, "Ribozymes as Potential Anti-HIV-1 Therapeutic Agents".
Haseloff and Gerlach, 334 Nature 585, 1988, "Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activation".
Sullenger et al., 63 Cell 601, 1990, "Overexpression of TAR Sequences Renders Cells Resistant to Human Immunodeficiency Virus Replication".
Sullenger et al., 10 Molecular and Cellular Biology 6512, 1990, "Expression of Chimeric tRNA-Driven Antisense Transcripts Renders NIH 3T3 Cells Highly Resistant to Moloney Murine Leukemia Virus Replication".
Izant et al., 1 Antisense Research and Development 371, 1991, "Chimeric Antisense RNAs".
Richardson et al., 67(7) Journal of Virology 3997-4005, 1993.

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