Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2005-09-13
2005-09-13
Nickol, Gary B. (Department: 1642)
Chemistry: molecular biology and microbiology
Vector, per se
C536S023100, C536S023500, C536S024100
Reexamination Certificate
active
06943011
ABSTRACT:
The Wilms' tumor gene associated with 11p3 locus on the human chromosome, as well as a method of analyzing cells for the gene is described and characterized. The gene encodes a transcription unit approximately 50 kb in size and a mRNA of approximately 3 kb, which is expressed in predominantly in kidney and gonadal tissue. The gene is alternative spliced producing four very similar mRNA transcripts. The polypeptides encoded by the Wilms' tumor DNA includes four “zinc fingers” and a region rich in proline and glutamine, suggesting that the polypeptide has a role in transcription regulation.
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Bruening Wendy
Buckler Alan J.
Call Katherine M.
Darveau Andre
Glaser Thomas M.
Hamilton Brook Smith & Reynolds P.C.
Massachusetts Institute of Technology
Nickol Gary B.
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