Local polymeric gel therapy

Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure

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623 11, 6048901, 6048911, A61F 206, A61F 202, A61K 922

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active

055758150

ABSTRACT:
A method for providing a synthetic barrier made of biocompatible polymeric materials in vivo which involves application of a material to a tissue or cellular surface such as the interior surface of a blood vessel, tissue lumen or other hollow space, is disclosed herein. The material may also be applied to tissue contacting surfaces of implantable medical devices. The polymeric materials are characterized by a fluent state which allows application to and, preferably adhesion to, tissue lumen surfaces, which can be increased or altered to a second less fluent state in situ; controlled permeability and degradability; and, in some embodiments, incorporation of bioactive materials for release in vivo, either to the tissue lumen surface or to the interior of the lumen.

REFERENCES:
patent: 2642874 (1953-06-01), Keeling
patent: 2854982 (1958-10-01), Pagano
patent: 3868956 (1975-03-01), Alfidi et al.
patent: 3880158 (1975-04-01), Gurney
patent: 3987000 (1976-10-01), Gleichenhagen et al.
patent: 4140126 (1979-02-01), Choudhury
patent: 4156067 (1979-05-01), Gould
patent: 4272518 (1981-06-01), Moro et al.
patent: 4377010 (1983-03-01), Fydelor et al.
patent: 4423725 (1984-01-01), Baran et al.
patent: 4445892 (1984-05-01), Hussein et al.
patent: 4448188 (1984-05-01), Loeb
patent: 4459252 (1984-07-01), MacGregor
patent: 4503569 (1985-03-01), Dotter
patent: 4520823 (1985-06-01), LeVeen et al.
patent: 4553545 (1985-11-01), Maass et al.
patent: 4573966 (1986-03-01), Weikl et al.
patent: 4580568 (1986-04-01), Glanturco
patent: 4610662 (1986-09-01), Weikl et al.
patent: 4636195 (1987-01-01), Wolinsky
patent: 4650466 (1987-03-01), Luther
patent: 4655746 (1987-04-01), Daniels et al.
patent: 4655771 (1987-04-01), Wallsten
patent: 4674506 (1987-06-01), Alcond
patent: 4690684 (1987-09-01), McGreevy et al.
patent: 4701509 (1987-10-01), Sun et al.
patent: 4702917 (1987-10-01), Schindler
patent: 4733665 (1988-03-01), Palmaz
patent: 4744366 (1988-05-01), Jang
patent: 4754752 (1988-07-01), Ginsburg et al.
patent: 4763654 (1988-08-01), Jang
patent: 4771777 (1988-09-01), Horzewski et al.
patent: 4781677 (1988-11-01), Wilcox
patent: 4799479 (1989-01-01), Spears
patent: 4820298 (1989-04-01), Leveen et al.
patent: 4832688 (1989-05-01), Sagae et al.
patent: 4938763 (1990-07-01), Dunn et al.
patent: 5059211 (1991-10-01), Stack et al.
patent: 5100429 (1992-03-01), Sinofsky et al.
patent: 5120829 (1992-09-01), Pierschbacher et al.
patent: 5126141 (1992-06-01), Henry
patent: 5147385 (1992-09-01), Beck et al.
patent: 5171217 (1992-12-01), March et al.
patent: 5213580 (1993-05-01), Slepian
patent: 5306249 (1984-04-01), Michel
patent: 5306250 (1994-04-01), March et al.
patent: 5306286 (1994-04-01), Stack et al.
patent: 5328470 (1994-07-01), Nabel et al.
patent: 5399352 (1995-03-01), Hanson
Clowes, Alexander W., et al., "Kinetics of Cellular Proliferation after Arterial Injury," Laboratory Investigation 52(6):611 (1985).
Clowes, Alexander W. and Stephen M. Schwartz, "Significance of Quiescent Smooth Muscle Migration in the Injured Rat Carotid Artey," Circulation Research 56(1) 139-145 (Jan. 1985).
Fogerty, Frances J., et al., "Inhibition of Binding of Fibronectin to Matrix Assembly Sites by Anti-Integrin (.alpha..sub.6 .beta..sub.1) Antibodies," J. Cell Biology, 111:699-708 (1990).
Geblsen, Kurt B., et al., "Inhibition of In Vitro Tumor Cell Invasion by Arg-Gly-Asp-containing Synthetic Peptides," J. Cell Biol. 106:925-930 (1988).
Ginsberg, Mark H., et al., "Cytoadhesins, Integrins, and Platelets," Thrombosis and Haemostasis 59(1):1-6 (1988).
Greene, T. W., and Wuts, P. G. M., "Protective Groups in Organic Synthesis", 2d Ed., John Wiley & Sons, Inc., pp. 317-318 (1991).
Humphries, Martin J., et al., "A Synthetic Peptide from Fibronectin Inhibits Experimental Metastasis of Murine Melanoma Cells," Science 233:467-470 (Jul. 1986).
Kerenyi, et al., "Local Enzymatic Treatment of Atheroscierotic Plaques," Experimental and Molecular Pathology, vol. 49, pp. 330-338 (1988).
McBride, et al., "Restenosis After Successful Coronary Angioplasty," N. Eng. J. Med., pp. 1734-1737 (1988).
Pierschbacher, Michael and Erkki Ruoslahti, "Variants of the cell recognition site of fibronectin that retain attachment-promoting activity," Proc. Natl. Sci. 81:5985-5988 (Oct. 1984).
Phillips, David R., et al., "The Platelet Membrane Glycoprotein IIb-IIIa Complex," Blood 71(4):831-843 (Apr. 1988).
Ruoslahti, Erkki and Michael D. Pierschbacter, "New Perspectives in Cell Adhesion: RGD and Integrins," Science 238:491-497 (Oct. 1987).
Vaheri, Antti, et al., "Codistribution of pericellular matrix proteins in cultured fibroblasts and loss in transformation: Fibronectin and procollagen," Proc. Natl. Acad. Sci. 75(10):4944-4948 (Oct. 1978).
Amaillay, Monique, et al., "The Cellular Interactions of Laminin Fragments," J. Biol. Chem. 262(24):11532-11538 (1987).
Boretos, "Improved Intravascular Delivery of Drug Vie a Polyethylene Jet Catheter," The 13th Annual Meeting of the Society of Biomaterials, p. 128.
Clowes, Alexander W., et al., "Kinetics of Cellular Proliferation after Arterial injury," Laboratory Investigation 49(3):327 (1983).

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