Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Arterial prosthesis – Stent structure
Reexamination Certificate
2005-03-29
2005-03-29
Isabella, David J. (Department: 3738)
Prosthesis (i.e., artificial body members), parts thereof, or ai
Arterial prosthesis
Stent structure
C623S001460
Reexamination Certificate
active
06872225
ABSTRACT:
An implant having a coating comprising a polymer matrix is swollen in a pharmaceutical solution whereby pharmaceutically active compound is imbibed into the polymer matrix. When the product is implanted, release of the pharmaceutically active compound from the coating takes place. The polymer is preferably formed from ethylenically unsaturated monomers including a zwitterionic monomer, most preferably 2-methacryloyloxyethyl-2′-trimethylammoniumethylphosphate inner salt. The monomers from which the polymer is formed may further include surface binding monomers, such as hydrophobic group containing monomers, and crosslinkable monomers, the content of which may be used to control the swellability. Preferably the implant is a stent and the coating of polymer on the exterior wall surface is thicker than the coating of polymer on the interior surface. Release of the drug may be controlled by selection of comonomers. The implant is suitably a stent for use in the cardiovascular system.
REFERENCES:
patent: 5304121 (1994-04-01), Sahatjian
patent: 5380299 (1995-01-01), Fearnot et al.
patent: 5562922 (1996-10-01), Lambert
patent: 5645883 (1997-07-01), Russell et al.
patent: 5648442 (1997-07-01), Bowers et al.
patent: 5674192 (1997-10-01), Sahatjian et al.
patent: 5705583 (1998-01-01), Bowers et al.
patent: 5735897 (1998-04-01), Buirge
patent: 5739236 (1998-04-01), Bowers et al.
patent: 5783650 (1998-07-01), Bowers et al.
patent: 5843089 (1998-12-01), Sahatjian et al.
patent: 5879697 (1999-03-01), Ding et al.
patent: 5897911 (1999-04-01), Loeffler
patent: 5900246 (1999-05-01), Lambert
patent: 5954706 (1999-09-01), Sahatjian
patent: 6090901 (2000-07-01), Bowers et al.
patent: 6251136 (2001-06-01), Guruwaiya et al.
patent: 6461631 (2002-10-01), Dunn et al.
patent: 6528080 (2003-03-01), Dunn et al.
patent: 197 44 135 (1999-03-01), None
patent: 0 623 354 (1994-04-01), None
patent: 0 897 701 (1999-02-01), None
patent: WO 92 11896 (1992-07-01), None
patent: WO 93 01221 (1993-01-01), None
patent: WO 94 21308 (1994-09-01), None
patent: WO 98 30615 (1998-07-01), None
patent: WO 00 04999 (2000-02-01), None
Andrew M. McNair, Using Hydrogel Polymers for Drug Delivery, Medical Device Technology, Dec. 1996, XP-000853790, pp 16-18, 21, 22.
Andrew M. McNair, Drug Delivery From Novel PC Hydrogels, Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 22, 1995, XP-000852752, pp 338-339.
D.C. Cumberland, et al, Biomimicry 1: PC, Cardiovascular Group, Clinical Sciences Centre, Northern General Hospital, Sheffield, UK, 1998 W.B. Saunders Company Ltd., XP 000853749, pp 149-150.
Tim A. Fishcell, MD, Polymer Coatings for Stents: Can We Judge a Stent by Its Cover?. 1996 American Heart Association, Inc., pp 1494-1495.
Willem J. Van Der Giessen, MD, PHD; et al, Marked Inflammatory Sequelae to Implantation of Biodegradeable and Nonbiodegradable Polymers in Porcine Coronary Arteries, Oct. 1, 1996 American Heart Association, Inc., Circulation vol. 94. No. 7, pp 1690-1697.
Rowan Lee
Stratford Peter William
Taylor Alistair Stewart
Vick Terrence Albert
Biocompatibles UK Limited
Isabella David J.
Sughrue & Mion, PLLC
Sweet Thomas J
LandOfFree
Local drug delivery does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Local drug delivery, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local drug delivery will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3383450