Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1993-12-10
1995-11-21
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424485, 424486, 424487, 424488, 514 2, 514 21, C08G 6308, C08G 6700, A61K 958
Patent
active
054685052
ABSTRACT:
A method of preventing adhesions by topical administration of fibrinolysis enhancing agents is described. The method uses a topically applied polymeric matrix for delivery of a fibrinolyic agent, preferably urokinase, or tPA. In the most preferred embodiment, the matrix is extremely thin and is polymerized in situ to form a biodegradable polymeric matrix. The matrix provides controlled release of the agent over a period of time effective to prevent surgical adhesions and is biodegradable, usually within the same time frame. Examples demonstrate that the combination of the matrix and the urokinase or tPA is effective in preventing surgical adhesions.
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Dunn Randall C.
Hill-West Jennifer L.
Hubbell Jeffrey A.
Board of Regents , The University of Texas System
Nutter Nathan M.
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