Local delivery of dipyridamole for the treatment of proliferativ

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

424422, 424489, 264 41, 600 36, 623 1, 604264, A61F 204, A61F 206, A61M 2501, A61K 914

Patent

active

053146883

ABSTRACT:
A method of inhibiting cell proliferation in mammals which comprises the local delivery of an inhibitory amount of dipyridamole. Inhibiting cell proliferation is useful for the treatment of proliferative diseases such as vascular restonesis, scleroderma, psoriasis, and rheumatoid arthritis. This method includes the local delivery of dipyridamole to the proliferative site by various techniques including local delivery catheters, site specific carriers, implants, direct injection, or direct application.

REFERENCES:
patent: 4427648 (1984-01-01), Brickl et al.
patent: 4824436 (1989-04-01), Wolinsky
patent: 5102668 (1992-04-01), Eichel et al.
patent: 5171217 (1992-12-01), March
Harker, et al., Arteriosclerosis, 10: 828a (Sep. 1990).
Schwartz, et al., The New England Journal of Medicine, 318: 1714-1719 (Jun. 1988).
Hermans, et al., American Heart Journal, 122: 171-187 (Jul. 1991).
Faxon, et al., The American Journal of Cardiology, 53: 72c-76c (Jul. 1984).
Bankhead, Medical World News: 26-34 (Feb. 1991).
Sanz, et al., Circulation, 82: 765-773 (Sep. 1990).
Beckett, et al., Arthritis and Rheumatism, 27: 1137-1143 (Oct. 1984).
Radic et al., J. Surg. Reso., "The Role of Aspirin and Intimal Hyperplasia Following Deenothialization", 41(1), 84-91 (1986) (Abstracts Only).
Takehara, et al., "Dipyridamole Decreases Platelet-Derived Growth Factor Levels in Human Serum", Arteriosclerosis, 7, No. 2, 152-158 (1987).
Landymore, et al., "The effects of Aspirin and Dipyridamole on Platelet Function and Prevention of Intimal Hyperplasia in Autologous Vein Grafts", The Canadian Journal of Cardiology, 4, No. 4, 56-59 (1988).
Ingermann-Wojenski, et al., "Model System to Study Interaction of Platelets with Damaged Arterial Wall", Experimental and Molecular Pathology, 48, No. 1, 116-134 (1988).
Lindblad, et al., "Effect of Anticoagulant and Antiplatelet Drugs on In Vitro Smooth Muscle Proliferation", Artery, 15, No. 4, 225-233 (1988).
Hagen, et al., "Antiplatelet Therapy Reduces Aortic Intimal Hyperplasia Distal to Small Diameter ascular Prostheses (PTFE) in NonHuman Primates", Annals of Surgery, 195, No. 3, 328-339, (1992).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Local delivery of dipyridamole for the treatment of proliferativ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Local delivery of dipyridamole for the treatment of proliferativ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local delivery of dipyridamole for the treatment of proliferativ will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1971337

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.