Local delivery of dipyridamole for the treatment of proliferativ

Details Local delivery of dipyridamole for the treatment of proliferativ Local delivery of dipyridamole for the treatment of proliferativ

1991-11-21

1993-12-14

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424423, 424424, 424425, 424426, 424450, 424484, 424489, 424 7808, A61F 202, A61K 914, A61K 3174, A61K 3722

Patent

active

052700470

ABSTRACT:
A method of inhibiting cell proliferation in mammals which comprises the local delivery of an inhibitory amount of dipyridamole. Inhibiting cell proliferation is useful for the treatment of proliferaive diseases such as vascular restonesis, scleroderma, psoriasis, and rheumatoid arthritis. This method includes the local delivery of dipyridamole to the proliferative site by various techniques including local delivery catheters, site specific carriers, implants, direct injection, or direct application.

REFERENCES:
patent: 4824436 (1989-04-01), Wolinsky
Takehara, et al., "Dipyridamole Decreases Platelet-Derived Growth Factor Levels in Human Serum", Arteriosclerosis, 7, No. 2, 152-158 (1987).
Landymore, et al., "The Effects of Aspirin and Dipyridamole on Platelet Function and Prevention of Intimal Hyperplasia in Autologous Vein Grafts", The Canadian Journal of Cardiology, 4, No. 4, 56-59 (1988).
Ingermann-Wojenski, et al., "Model System to Study Interaction of Platelets with Damaged Arterial Wall", Experimental and Molecular Pathology, 48, No. 1, 116-134 (1988).
Lindblad, et al., "Effect of Anticoagulant and Antiplatelet Drugs on In Vitro Smooth Muscle Proliferation", Artery, 15, No. 4, 225-233 (1988).
Hagen, et al., "Antiplatelet Therapy Reduces Aortic Intimal Hyperplasia Distal to Small Diameter ascular Prostheses (PTFE) in NonHuman Primates", Annals of Surgery, 195, No. 3, 328-339, (1992).
Radic et al., "The role of aspirin and dipyramidole on vascular DNA synthesis and intimal hyperplasia following deendothialization", J. Surg. Res., 41(1), 84-91, 1986. (Abstract only).
Harker, et al., Arteriosclerosis 10: 828a (Sep. 1990).
Schwartz, et al., The New England Journal of Medicine 318: 1714-1719 (Jun., 1988).
Hermans, et al., American Heart Journal 122: 171-187 (Jul. 1991).
Faxon, et al., The American Journal of Cardiology 53: 72c-76c (Jul. 1984).
Bankhead, Medical World News: 26--34 (Feb. 1991).
Sanz, et al., Circulation 82: 765-773 (Sep. 1990).
Beckett, et al., Arthritis and Rheumatism 27: 1137-1143 (Oct. 1984).

Affiliated with

Also associated with

Rating

Local delivery of dipyridamole for the treatment of proliferativ does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Local delivery of dipyridamole for the treatment of proliferativ, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local delivery of dipyridamole for the treatment of proliferativ will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1703315