Dentistry – Method or material for testing – treating – restoring – or...
Patent
1985-07-26
1987-08-11
Wilson, John J.
Dentistry
Method or material for testing, treating, restoring, or...
433 80, 433136, 604890, A61C 500
Patent
active
046858830
ABSTRACT:
A method for local delivery of chemotherapeutic agent (12) to a localized site in the mouth is disclosed. The method of delivery includes displacement or reflection of gingival tissues (20) from the tooth, in the area to be treated, to facilitate access to the periodontal lesion (16). A biodegradable, time-release microsphere (10) capsulating the chemotherapeutic agent is next positioned in the lesion (16). Accordingly, localized delivery of chemotherapeutic agent (12) continuously over a predetermined period of time is provided.
REFERENCES:
patent: 2174796 (1939-10-01), Luzzi
patent: 2835628 (1958-05-01), Saffir
patent: 3811444 (1974-05-01), Heller et al.
patent: 3887699 (1975-06-01), Yelles
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 3991766 (1976-11-01), Schmitt et al.
patent: 4001388 (1977-01-01), Shell
patent: 4121940 (1978-10-01), Michel et al.
patent: 4175326 (1979-11-01), Goodson
patent: 4249531 (1981-02-01), Heller et al.
patent: 4250163 (1981-02-01), Negai et al.
patent: 4276880 (1981-07-01), Malmin
patent: 4321038 (1982-03-01), Porteous
"Timed-Release Anesthetic Developed", The Washington Post, Mar. 6, 1985.
Goodson, J. M., Haffajee, A. and Socransky, S. S.: Periodontal Therapy by Local Delivery of Tetracycline. J. Clin. Periodontal 6:83, 1979.
Lindhe, J. et al.: Local Tetracycline Delivery Using Hollow Fiber Devices in Periodontal Therapy., J. Clin. Periodontal, 6:141, 1979.
Goodson, J. M. et al.: Monolithic Tetracycline-Containing Fibers for Controlled Delivery to Periodontal Pockets., J. Clin. Periodontal 54:575, Oct. 1983.
The Effect of Long-Term Low-Dose Tetracycline Therapy on the Subgingival Microflora in refractory Adult Periodontitis, K. S. Kornman et al., Journal of Periodontology, 1982:53:604-610.
The Development and in Vitro Evaluation of Acrylic Strips and Dialysis Tubing for Local Drug Delivery, M. Addy et al., Journal of Periodontology, 1982:53:693-699.
Tetracycline and its Derivatives Strongly Bind to and are released from the Tooth Surface in Active Form, P. J. Baker et al., Journal of Periodontology 1983:54:580-585.
Subgingival Metronidazole in Acrylic Resin vs. Chlorhexidine Irrigation in the Control of Chronic Periodontitis, F. I. S. Yeung et al., Journal of Periodontology, 1983:54:651-657.
Subgingival Metronidazole in Dialysis Tubing and Subgingival Chlorhexidine Irrigation in the Control of Chronic Inflammatory Periodontal Disease, W. Z. A. Wan Yusof et al., Journal of R. Clinical Periodontology, 1984:11:166-175.
Comparison of the Immediate Effects on the Subgingival Microflora of Acrylic Strips Containing 40% Chlorhexidine Metronidazole or Tetracycline, M. Addy et al., Journal of Clinical Periodontology, 1984:11:379-386.
Simple Bacteriological Methods to Assess Changes in Subbingival Microflora Produced by Metronidazole-Containing Acrylic Strips Placed into Periodontal Pockets, M. Addy et al., Journal of Clinical Periodontology, 1984:11:467-474.
Slow Release Metronidazole and a Simplified Mechanical Oral Hygiene Regimen in the Control of Chronic Periodontitis, H. N. Newman et al., Journal of Clinical Periodontology, 1984:11:576-582.
Clinical Responses Following Periodontal Treatment by Local Drug Delivery, J. M. Goodson et al., Journal of Periodontology, Supplement 1985:81-87.
Tetracyclines Inhibit Tissue collagenases: Effects of Ingested Low-Dose and Local Delivery Systems, L. M. Golub et al., Journal of Periodontology, Supplement, 1985:93-97.
Freeze-Dried Bone Allografts Combined with Tetracycline in the Treatment of Juvenile Periodontitis, Thomas W. Mabry et al., Journal of Periodontology, 1985:56:74-81.
Periodontal Disease Treatment by Local Drug Delivery, J. M. Goodson, Journal of Periodontology, 1985:56:265-272.
Clinical and Microbiological Effects of Sustained Release chlorhexidine in Periodontal Pockets, A. Stabholz et al., Journal of Clinical Periodontology, 1986:13:783-788.
Gum Disease Alleviated by Pellets, Patricia R. Raber, Dentistry Today, vol. 5, No. 5, Jun. 1986.
Kakehashi, S. and Parakkal, P. F.: Proceedings From the State of the Art Workshop on Surgical Therapy for Periodontitis., J. Periodontal 53:475, 1982.
Genco, R. J.: Antibiotics in the Treatment of Human Periodontal Diseases., J. Periodontal 52:545, 1981.
LandOfFree
Local delivery of chemotherapeutic agents for the treatment of p does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Local delivery of chemotherapeutic agents for the treatment of p, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local delivery of chemotherapeutic agents for the treatment of p will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-400604