Local administration of phosphodiesterase inhibitors for the tre

Details Local administration of phosphodiesterase inhibitors for the tre Local administration of phosphodiesterase inhibitors for the tre

1998-10-27

2000-03-14

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3150

Patent

active

060373466

ABSTRACT:
A method is provided for treating erectile dysfunction in a mammalian male individual. The method involves the local administration of a phosphodiesterase inhibitor or a pharmaceutically acceptable salt, ester, amide or derivative thereof within the context of an effective dosing regimen. A preferred mode of administration is transurethral. Pharmaceutical formulations and kits are provided as well.

REFERENCES:
patent: 3819631 (1974-06-01), Broughton et al.
patent: 3933822 (1976-01-01), Broughton et al.
patent: 4039544 (1977-08-01), Broughton et al.
patent: 4666908 (1987-05-01), Hamilton
patent: 4801587 (1989-01-01), Voss et al.
patent: 5145852 (1992-09-01), Virag
patent: 5242391 (1993-09-01), Place et al.
patent: 5250534 (1993-10-01), Bell et al.
patent: 5272147 (1993-12-01), Bell et al.
patent: 5346901 (1994-09-01), Bell et al.
patent: 5426107 (1995-06-01), Bell et al.
patent: 5506347 (1996-04-01), Erion et al.
Bush et al. (1992), "Nitric Oxide is a Potent Relaxant of Human and Rabbit Corpus Cavernosum," The Journal of Urology 147(6):1650-1655.
Doherty (1997), "Oral, Transdermal, and Transurethral Therapies for Erectile Dysfunction," Male Infertility and Dysfunction, Hellstron, ed., Chapter 33 (New York, New York: Springer-Verlag Hellstrom), pp. 452-467.
Rajfer et al. (1992), "Nitric Oxide as a Mediator of Relaxation of the Corpus Cavernosum in Response to Nonadrenergic, Noncholinergic Neurotransmission," The New England Journal of Medicine 326(2):90-94.
Taher et al. (1992), "Cyclic nucleotide phosphodiesterase activity in human cavernous smooth muscle and the effect of various selective inhibitors," International Journal of Impotence Research (Supplement 2) 4:11.
Trigo-Rocha et al. (1993), "The Role of Cyclic Adenosine Monophosphate, Cyclic Guanosine Monophosphate, Endothelium and Nonadrenergic, Noncholinergic Neurotransmission in Canine Penile Erection," The Journal of Urology 149(4):872-877.

Affiliated with

Also associated with

Rating

Local administration of phosphodiesterase inhibitors for the tre does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Local administration of phosphodiesterase inhibitors for the tre, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Local administration of phosphodiesterase inhibitors for the tre will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-169421