Loading of hydrophobic drugs into hydrophilic polymer...

Details Loading of hydrophobic drugs into hydrophilic polymer... Loading of hydrophobic drugs into hydrophilic polymer...

2011-08-30

2011-08-30

Foley, Shanon A (Department: 1619)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C514S291000, C514S449000, C514S180000, C514S570000, C264S004330

Reexamination Certificate

active

08007831

ABSTRACT:
A process is described for loading hydrophilic polymer particles with a water-insoluble solvent-soluble drug. The particles are preferably embolic agents. The method provides particles having little or no drug at the surface and in a surface layer, whereby the burst effect is minimised. The drug is precipitated in the core of the particle, leading to extended release. The drug is, for instance, paclitaxel, rapamycin, dexamethasone or ibuprofen.

REFERENCES:
patent: 5270354 (1993-12-01), Vermeersch et al.
patent: 5508060 (1996-04-01), Perman et al.
patent: 6214387 (2001-04-01), Berde et al.
patent: 7001616 (2006-02-01), Batich et al.
patent: 2003/0202936 (2003-10-01), Batich et al.
patent: 2004/0071768 (2004-04-01), Sarris et al.
patent: 2005/0163914 (2005-07-01), Klee et al.
patent: 98/17256 (1998-04-01), None
patent: WO 2004/073688 (2004-02-01), None
Vandelli et al. Microwave Treated Gelatin Microspheres as Drug Delivery System. Journal of Controlled Release, vol. 96. 2004.
Vandelli et al. Microwave-treated gelatin microspheres as drug deliver system, Journal of Controlled Release, vol. 96, 2004.
Maria Angela Vandelli et al., “Microwave-treated gelatin microspheres as drug delivery system”, Journal of Controlled Release, vol. 96 (2004), pp. 67-84.

Affiliated with

Also associated with

Rating

Loading of hydrophobic drugs into hydrophilic polymer... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Loading of hydrophobic drugs into hydrophilic polymer..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Loading of hydrophobic drugs into hydrophilic polymer... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2667652