LLG polypeptides of the triacylglycerol lipase family, and...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S019000, C435S069100, C435S252300, C435S320100, C424S094600, C530S326000, C536S023200

Reexamination Certificate

active

07056720

ABSTRACT:
The present invention relates to LLG polypeptides, which are polypeptides of the triacylglycerol lipase family, and fragments thereof, antibodies against such polypeptides, nucleic acids encoding such polypeptides, and antisense nucleic acids derived from such nucleic acids. The invention relates also to therapeutic compositions and methods comprising the above. In addition, the invention relates to the preparation of LLG polypeptides using recombinant technology and to the use of LLG polypeptides to screen for agonists and antagonists thereof.

REFERENCES:
patent: 4944944 (1990-07-01), Tang et al.
patent: 5616483 (1997-04-01), Bjursell et al.
patent: 5691181 (1997-11-01), Lowe
patent: 5858755 (1999-01-01), Lowe
patent: 5998189 (1999-12-01), Blanchard et al.
patent: 6337187 (2002-01-01), Kapeller-Libermann
patent: 6395530 (2002-05-01), Jaye et al.
patent: 6558936 (2003-05-01), Khodadoust et al.
patent: 6797502 (2004-09-01), Kapeller-Libermann
patent: 6864064 (2005-03-01), Kapeller-Libermann
patent: 2003/0108538 (2003-06-01), Jaye et al.
patent: WO 94/20619 (1994-09-01), None
Gershenwald, J.E., et al., 1985, “Monoclonal antibodies to avian lipoprotien lipase. Purification of the enzyme by immunoaffininty chromatography”, Biochimica et Biophysical Acta, vol. 836, pp. 286-295 (Abstract Only).
Cooper, D.A., et al., 1989, “Avian lipoprotein lipase: cDNA sequence and reciprocal regulation of mRNA levels in adipose and heart”, Biochimica et Biophysical Acta, vol. 1008, pp. 92-101.
Stahnke, G., et al., 1987, “Human hepatic triglyceride lipase: cDNA cloning, amino acid sequence and expression in a cultured cell line”, Differentiation, vol. 35, pp. 45-52.
Datta, S., et al., 1988, “Human hepatic lipase”, The Journal of Biological Chemistry, vol. 263, pp. 1107-1110.
Ikeda, et al., 1990, “A sandwich-enzyme immunoassay for the quantification of lipoprotien lipase and hepatic tryglyceride lipase in human postheparing plasma . . . ”, Journal of Lipid Research, vol. 31, pp. 1911-1924.
Jaye, M., et al., 1999, “A novel endothelial-derived lipase that modulates HDL metabolism”, Nature Genetics, vol. 21, pp. 424-428.
Hirata, K., et al., 1999, “Cloning of a unique lipase from endothelial cells extends the lipase gene family”, The Journal of Biological Chemistry, vol. 274, pp. 14170-14175.
McCoy, M.G., et al., 2002, “Characterization of the lipolytic activity of endothelial lipase”, Journal of Lipid Research, vol. 43, pp. 921-929.
Amman, E. et al., Tightly Regulated tac Promoter Vectors Useful for the Expression of Unfused and Fused Proteins inEscherichia coli, Gene(1988), 69: 301-315.
Auffray, C. et al., GenBank Database, Accession No. Z44958 (1994).
Berkner, K., Development of Adenovirus Vectors for the Expression of Heterologous Genes,Biotechniques(1988), 6:616-29.
Brady, L. et al., A Serine Protease Triad Forms the Catalytic Centre of a Triacylglycerol Lipase,Nature(Feb. 22, 1990), 343: 767-769.
Carlton, V.E.H. et al., Mapping of a Locus for Progressive Familial Intrahepatic Cholestasis (Byler Disease) to 18q21-q22, the Benign Recurrent Intrahepatic Cholestasis Region,Hum. Mol. Genet.(1995), 4: 1049-1053.
Chappell, D.A. et al., Cellular Catabolism of Normal Very Low Density Lipoproteins via the Low Density Lipoprotein Receptor-related Protein/ α2-Macroglobulin Receptor is Induced by the C-terminal Domain of Lipoprotein Lipase,J. Biol. Chem.(Jul. 8, 1994), 269: 18001-18006.
Chowers, Y. et al., The Vδ1 T Cell Receptor Repertoire in Human Small Intestine and Colon,J. Exp. Med.(1994), 180:183-190.
Chowers, Y. et al., GenBank Database, Accession No. L32416 (1995).
Dugi, K. et al., Human Hepatic and Lipoprotein Lipase: The Loop Covering the Catalytic Site Mediates Lipase Substrate Specificity,J. of Biol. Chem.(Oct. 27, 1995), 270: 25396-25401.
Faustinella, F. et al., Functional Topology of a Surface Loop Shielding the Catalytic Center in Lipoprotein Lipase,Biochemistry(1992), 31: 7219-7223.
Ghosh, S. et al., Molecular Cloning and Expression of Rat Hepatic Neutral Cholesteryl Ester Hydrolase,Biochem. Biophys. Acta(1995), 1259: 305-312.
Giller, T. et al., Two Novel Human Pancreatic Lipase Related Proteins, hPLRP1 and hPLRP2,J. Biol. Chem.(Aug. 15, 1992), 267: 16509-16516.
Hide, W.A. et al., Structure and Evolution of the Lipase Superfamily,J. Lipid Res.(1992), 33: 167-178.
Houwen, R.H.J. et al., Genome Screening by Searching for Shared Segments: Mapping a Gene for Benign Recurrent Intrahepatic Cholestasis,Nature Genet.(Dec. 1994), 8: 380-386.
Ishizaki, K. et al., The Biochemical Studies on Phalloidin-Induced Cholestatsis in Rats,Toxicol. Lett.(1997), 90: 29-34.
Liu, M. et al., Alteration of Lipd Profiles in Plasma of Transgenic Mice Expressing Human Lipoprotein Lipase,J. Biol. Chem.(Apr. 15, 1994), 269: 11417-11424.
Lo, J. et al., Lipoprotein Lipase: Role of Intramolecular Disulfide Bonds in Enzyme Catalysis,Biochemical and Biophysical Res. Commun.(Jan. 5, 1995), 206: 266-271.
Ma, Y. et al., Mutagenesis in Four Candidate Heparin Binding Regions (Residues 279-282, 291-304, 390-393, and 439-448) and Identification of Residues Affecting Heparin Binding in Human Lipoprotein Lipase,J. Lipid Res.(1994), 35: 2049-2059.
Marra, M. et al., GenBank Database, Accession No. AA137809 (1996).
Martin, G. et al., Isolation and cDNA Sequence of Human Postheparin Plasma Hepatic Triglyceride Lipase,J. of Biol. Chem.(1988), 263: 10907-10914.
Nordestgaard, B.G. et al., Atherosclerosis and Arterial Influx of Lipoproteins,Curr. Opin. Lipidol.(1994), 5: 252-257.
Olivecrona, G. and T. Olivecrona, Triglyceride Lipases and Atherosclerosis,Curr. Opin. Lipidol.(1995), 6: 291-305.
Ranganathan, G. et al., Tissue Specific Expression of Human Lipoprotein Lipase,J. Biol. Chem.(Mar. 31, 1995), 270: 7149-7155.
Rutledge, J.C. and I.J. Goldberg, Lipoprotein Lipase (LpL) Affects Low Density Lipoprotein (LDL) Flux Through Vascular Tissue: Evidence that LpL Increases LDL Accumulation in Vascular Tissue,J. Lipid Res.(1994), 35: 1152-60.
Semenkovich, C.F. et al.,In VitroExpression and Site-specific Mutagenesis of the Cloned Human Lipoprotein Lipase Gene,J. Biol. Chem.(Apr. 5, 1990), 265: 5429-5433.
Shimada, M. et al., Overexpression of Human Lipoprotein Lipase in Transgenic Mice,J. Biol. Chem.(Aug. 25, 1993), 268: 17924-17929.
Strautnieks, S.S. et al., Locus Heterogeneity in Progressive Familial Intrahepatic Cholestasis,J. Med. Genet.(1996), 33: 833-836.
van Tilbeurgh, H. et al., Lipoprotein Lipase,J. of Biol. Chem.(Feb. 11, 1994), 269: 4626-4633.
Verhoeven, A.J.M. et al., Hepatic Lipase Gene is Transcribed in Rat Adrenals into a Truncated mRNA,J. Lipid Res.(1994), 35: 966-975.
Warren, R. et al., Rabbit Hepatic Lipase cDNA Sequence: Low Activity is Associated with Low Messenger RNA Levels,J. of Lipid Res.(1991), 32: 1333-1339.
Williams, K.J., The Response-to-Retention Hypothesis of Early Atherogenesis,Art. Thromb. and Vasc. Biol.(1995), 15: 551-561.
Winkler, F.K. et al., Structure of Human Pancreatic Lipase,Nature(Feb. 22, 1990), 343: 771-774.
Wong, H. et al., Lipoprotein Lipase Domain Function,J. of Biol. Chem.(Apr. 8, 1994), 269: 10319-10323.
Wong, H. et al., Domain Exchange: Characterization of a Chimeric Lipase of Hepatic Lipase and Lipoprotein Lipase,Proc. Natl. Acad. Sci. USA(Dec. 1991), 88:11290-11294.
Zambon, A. et al., Prevention of Raised Low-Density Lipoprotein Cholesterol in a Patient with Familial Hypercholesterolaemia and Lipoprotein Lipase Deficiency,Lancet(May 1, 1993), 341: 1119-1121.
Zilversmit, D.B., A Proposal Linking Atherogenesis to the Interaction of Endothelial Lipoprotein Lipase with Triglyceride-Rich Lipoproteins,Circ. Res.(Dec. 1973), 33: 633-638.
Zilversmit, D.B., Atherogenic Nature of Triglycerides, Postprandial Lipidemia, and Triglyceride-Rich Remnant Lipoproteins,Clin. Chem.(1995), 41: 153-158.
Mahaney et al., A Major Locus Influencing Plasma High-Density Lipoprotein Cholesterol Levels in the San Antonio Family Heart Study,Arterioscler. Thromb.(Oct. 1995), 15:1730-39.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

LLG polypeptides of the triacylglycerol lipase family, and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with LLG polypeptides of the triacylglycerol lipase family, and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and LLG polypeptides of the triacylglycerol lipase family, and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3703002

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.