LL-1 tumor specific genes

Details LL-1 tumor specific genes LL-1 tumor specific genes

1997-01-27

1998-09-22

Huff, Sheela

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

536 235, C07K 100, C07K 1400, C07K 1700

Patent

active

058115196

ABSTRACT:
The invention describes the LL-1 tumor specific gene family, including fragments and biologically functional variants thereof. Also included are polypeptides and fragments thereof encoded by such genes, and antibodies relating thereto. Methods and products also are provided for diagnosing and treating conditions characterized by expression of a LL-1 gene product.

REFERENCES:
patent: 5342774 (1994-08-01), Boon et al.
patent: 5405940 (1995-04-01), Boon et al.
Traversari, et al., Immunogenetics 35:145 (1992).
van der Bruggen, et al. Science 254:1643-1647 (1991).
Rammensee, et al., Immunogenetics 41:178-228 (1995).
Van den Evnde, et al., Curr. Opinion in Immun. 7:674-681 (1995).
De Plaen et al., Immunogenetics 40:360-369. (1994).
Coulie et al., Stem Cells 13:393-403. (1995).
Hubank and Schatz, Nucl. Acids Res. 22:5640. (1994).

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