Liver stem cell

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Animal cell – per se – expressing immunoglobulin – antibody – or...

Reexamination Certificate

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C424S093210

Reexamination Certificate

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07935528

ABSTRACT:
The invention provides a primary liver stem cell and a cell doublet consisting of a hepatocyte and the stem cell, both of which are derived from normal liver tissue. Methods of isolating the cells, genetically altering the cells, and using the cells for transplantation are also within the invention.

REFERENCES:
patent: 6129911 (2000-10-01), Faris
patent: WO 93/03142 (1993-02-01), None
Sell et al. (1990) Cancer Research, vol. 50, 3811-3815.
Allison et al. (1998) Curr. Opin. Cell Biol., vol. 10, 710-715.
Deonarain et al. (1998) Exp. Opin. Ther. Patents, vol. 8 (1), 53-69.
Miller et al. (1995) FASEB, vol. 9, 190-199.
Hixson et al. (1997) Carcinogenesis, vol. 18(6), 1169-1175.

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