Liver specific chimeric regulatory sequence and use thereof

Details Liver specific chimeric regulatory sequence and use thereof Liver specific chimeric regulatory sequence and use thereof

2011-07-05

2011-07-05

Dunston, Jennifer (Department: 1636)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of detaching cells, digesting tissue or establishing...

C435S455000, C435S370000, C435S366000, C536S024100

Reexamination Certificate

active

07972851

ABSTRACT:
The present invention relates to a chimeric regulatory sequence with liver cell specificity. The chimeric regulatory sequence includes a proximal regulatory sequence and a distal enhancer 5′ flanking region of human α-fetoprotein (AFP) gene. The chimeric regulatory sequence is useful in purified specific lineages, such as liver cells, from other cell lineages.

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Su et al. Selective killing of AFP-positive hepatocellular carcinoma cells by adeno-assocaited virus transfer of the herpes simplex virus thymidine kinase gene. Hum Gene Ther. vol. 7, No. 4, pp. 463-470, Mar. 1996.
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