Liver protection compounds of the cyclohexenone type from...

Details Liver protection compounds of the cyclohexenone type from... Liver protection compounds of the cyclohexenone type from...

2007-09-24

2008-11-25

Witherspoon, Sikarl A (Department: 1621)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

C568S377000

Reexamination Certificate

active

07456225

ABSTRACT:
The present invention relates to a compound ofAntrodia camphorataused for liver protection, in particular to an extract, 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone which is isolated fromAntrodia camphorata. The cyclohexenone compound according to the invention helps to alleviate liver injury and fibrosis induced by chemicals and reduces the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). By increasing the contents of glutathione peroxidase (GSHPx) and catalase (CAT), cyclohexenone further decreases the liver damage and the oxidative pressure caused by free radicals, enhances the antioxidant ability and achieves the purposed of liver protection.

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Wang et al., “Continuous Cell Line from Pupal Ovary ofPerina nuda(Lepidoptera: Lymantriidae) That Is Permissive to Nuclear Polyhedrosis Virus fromP. nuda,” Journal of Invertebrate Pathology, vol. 67, 1996, pp. 199-204.

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