Liver preservation

Refrigeration – Material cooling means including gas-liquid contactor – Means feeding gas into pressurized receiver

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Details

62 78, 62384, 435 1, B01F 304

Patent

active

042428831

ABSTRACT:
A method and apparatus for perfusing livers comprising a portable container and a liver receptacle removably positioned in such container. Portions of the receptacle are spaced from the walls of the container when the receptacle is in position so that ice may be positioned around the receptacle. A perfusate holder is mounted on the container. A second container surrounds a portion of the holder and is adapted to receive ice. An intermittently operated flow regulator controls gravity flow of perfusate at predetermined rate from the holder to the receptacle and a timer controls operation of controller at predetermined time intervals.

REFERENCES:
patent: 3406531 (1968-10-01), Swenson et al.
patent: 3545221 (1970-12-01), Swenson et al.
patent: 3545225 (1970-12-01), Swenson et al.
patent: 3607646 (1971-09-01), Roissart
patent: 3753865 (1973-08-01), Belzer et al.
patent: 3777507 (1973-12-01), Burton et al.
patent: 3810367 (1974-05-01), Peterson
patent: 3914954 (1975-10-01), Doerig
Toledo, L. H. et al., 1975 Ann. Surg. 181: 289-298 Factors Determining Successful Liver Preservation for Transplant.
Toledo, L. H. et al., Forty Eight Hrs. Hypothermic Pulsatile Perfusion of Canine Hearts before Transplantation, Cryobiology 16, 1979, pp. 343-349.
Calne, R. Y. et al., Liver Preservation by Single Passage Hypothermic Squirt Perfusion; British Medical Journal, 1972, 4, pp. 142-144.

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