Liver function breath test using aromatic amino acids

Details Liver function breath test using aromatic amino acids Liver function breath test using aromatic amino acids

1993-06-11

1995-02-07

Stoll, Robert L.

Surgery

Truss

Pad

128719, 128898, A61B 508, A61B 600

Patent

active

053868323

ABSTRACT:
A test for determining hepatic function has been developed. This test uses oral administration of isotope labeled phenylalanine or tyrosine, particularly .sup.13 C-phenylalanine, in a rapid breath test. In the preferred mode, the breath sample is analyzed using a mass spectrometer and compared with a standard. The breath test provides a dynamic rather than static determination of hepatic function and can be used for both early and late stage liver problems.

REFERENCES:
patent: 4830010 (1989-05-01), Marshall
patent: 5100779 (1992-03-01), Watkins
Shanbhogue et al., "Whole Body Leucine, Phenylalanine, and Tyrosine Kinetics in End-Stage Liver Disease Before and After Hepatic Transplantation" Metabolism Nov. 1987, vol. 36, No. 11, pp. 1047-1053, as abstracted in Medline, AN88038269.
Baker et al., "The aminopyrine breath test does not correlate with histologic disease severity . . . ," Hepatology, (1987 May-Jun.), 7(3):464-7, as abstracted in Medline AN87192470.
Schoeller et al., "Comparison of different methods expressing results of the aminopyrine breath test . . . ," Hepatology, (1982 Jul.-Aug.), 2(4):455-62 as abstracted in Medline, AN 82237831.
Hehir et al., "Abnormal Phenylalanine Hydroxylation and Tyrosine Oxidation in a Patient With Acute Fulminant Liver Disease With Correction by Liver Transplantation" Gastroenterology 1985, vol. 89, No. 3, pp. 659-663.
Neale et al., "The metabolism of .sup.14 C-labelled essential amino acids given by intragastric or intravenous infusion to rats on normal and protein-free diets" British Journal of Nutrition 1974, vol. 32, pp. 11-25.
Ball et al., "Influence of dietary protein concentration on the oxidation of phenylalanine by the young pig" British Journal of Nutrition 1986, vol. 55, pp. 651-658.

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