Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1997-02-10
1999-08-10
Ulm, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
435 695, 435 712, 4351723, 4352523, 4353201, 435325, 930140, 536 235, C07K 1452, C12N 1519
Patent
active
059360682
ABSTRACT:
The present invention provides nucleotide and amino acid sequences that identify and encode novel expressed chemokines (ECs) from liver and pituitary gland tissues. The present invention also provides for antisense molecules to the nucleotide sequences which encode ECs, expression vectors for the production of purified ECs, antibodies capable of binding specifically to ECs, hybridization probes or oligonucleotides for the detection of EC-encoding nucleotide sequences, genetically engineered host cells for the expression of ECs, diagnostic tests for inflammation or disease based on on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs, pharmaceutical compositions to treat inflammation or disease based on EC-encoding nucleic acid molecules or antibodies capable of binding specifically to ECs.
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Thomas J. Schall, "The Chemokines" The Cytokine Handbook, Academic Press, 1994, Sep. 19-20, 1994, Second Edition, pp. 180-272.
Opdenakker et al., "The Human MCP-3 Gene (SCYA1): Cloning, Sequence Analysis and Assignment 50 the C-C Chemokine Gene Cluster on Chromosome" Genomics 21:403-408 (1996).
Yoshida et al., "Molecular Cloning of a Novel C or Gamma Type Chemokine, SCM-1" FEBS Letters 360:155-159 (1995).
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Bandman Olga
Hawkins Phillip R.
Seilhamer Jeffrey J.
Wilde Craig G.
Billings Lucy J.
Incyte Pharmaceuticals Inc.
Mertz Prema
Mohan-Peterson Sheela
Ulm John
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