Liver-derived receptors for advanced glycosylation endproducts a

Details Liver-derived receptors for advanced glycosylation endproducts a Liver-derived receptors for advanced glycosylation endproducts a

1991-08-23

1996-12-17

Walsh, Stephen G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 8, 530350, 530395, 930 10, C07K 14705, A61K 3817

Patent

active

055853447

ABSTRACT:
The present invention relates to receptors for advanced glycosylation endproducts derived from rat liver membranes, and that specifically comprise proteins determined to possess molecular masses of about 90 kD and 60 kD, respectively, as assessed by migration during SDS-PAGE. Partial N-terminal sequences have been determined and diagnostic and therapeutic agents, compositions and methods are proposed.

REFERENCES:
patent: 5202424 (1993-04-01), Vlassara et al.
Radoff et al, "Isolation of a Macrophage Receptor . . . " Fed. Proc. 46(6):2116, abstract #1112 (May 1987).
Yang, Z., et al. J. Exp. Med. 174:515-524 published on Aug. 23, 1991.
Vlassara, H. et al. Proc. Natl. Acad. Sci. U.S.A. 82:5588 (1985).
Vlassara, H. et al. J. Exp. Med. 160:197 (1984).
Radoff, S. Diabetes 39:1510 (1990).
Radoff, S., et al. Arch Biochem. Biophys. 263:418 (1988).
Esposito, C. et al. J. Exp. Med. 170:1387 (1989).
Skolnik, E. et al. J. Exp. Med. 174:931-939 (1991).
M. Kirstein et al., Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: Role in vascular disease of diabetes and aging, Proc. Natl. Acad. Sci. USA, 87:9010-9014, Nov. 1990.

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