Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1995-04-10
1998-12-22
Elliott, George C.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 931, 424 934, 4241841, 4242581, 4242001, 4242011, 4242031, A61K 3500, A61K 3902, A61K 39112
Patent
active
058515194
ABSTRACT:
The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine.
In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
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Chatfield Steven Neville
Dorman Charles James
Dougan Gordan
Higgins Christopher Francis
Elliott George C.
Garry Sean M
Glaxo Wellcome Inc.
The Lister Institute of Preventive Medicine
The Royal Society
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