Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1982-11-29
1984-09-18
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
435253, A61K 39112, C12N 120
Patent
active
044723784
ABSTRACT:
A novel live vaccine for the prevention of salmonellosis in water fowl comprising essentially a suspension of living culture of the attenuated strain Salmonella typhi-murium No. 3, deposited at the All-Union State Research Control Institute for Veterinary Preparations, the USSR Ministry of Agriculture (No. 121), in a concentration of 2-4 billion microbe cells per 10 cm.sup.3 of drinking water. A process for making said vaccine, wherein the attenuated strain Salmonella typhi-murium No. 3 is cultivated in a culture medium containing sources of carbon, nitrogen, mineral salts, biologically active substances at a temperature of 37.degree.-38.degree. C. to produce the highest attainable accumulation of biomass during a period of 10-14 hours with subsequent drying and obtainment of the vaccine.
A method of specific prophylaxis of salmonellosis in water fowl, wherein the live vaccine is administered to the poultry twice orally at a 2-3 days interval in a dose of 2 billion microbe cells at the first, and 4 billion microbe cells at the second, feeding, being combined with drinking water.
REFERENCES:
patent: 4350684 (1982-09-01), Pardon et al.
Guschin Vyacheslav N.
Kirzhaev Fedor S.
Kosikov Anatoly M.
Likhoded Vladimir G.
Malakhov Jury A.
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