Live vaccine for human immunodeficiency virus

Details Live vaccine for human immunodeficiency virus Live vaccine for human immunodeficiency virus

2007-03-13

2007-03-13

Parkin, J. S. (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

C424S208100

Reexamination Certificate

active

09244195

ABSTRACT:
The present invention discloses development of a model live vaccine for HIV, using an attenuated strain ofSalmonellaengineered to surface express specific HIV proteins and testing of this vaccine in mice. There are provided two recombinant plasmids, containing the Lpp-OmpA genes required for surface exposure, followed by the genes for the HIV-1 proteins, Reverse Transcriptase or Transactivating protein (Tat). These plasmids are electroporated into an attenuated strain ofSalmonella, and antigen expression is verified. These live vaccines are then used to orally inoculate mice and the vaccinated mice are tested for fecal IgA response and helper T cell response specific for the HIV antigens.

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