Live vaccine for bovine babesiosis and method of preparation

Details Live vaccine for bovine babesiosis and method of preparation Live vaccine for bovine babesiosis and method of preparation

1984-10-31

1986-05-20

Hazel, Blondel

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

435258, 424 88, A61K 39018, C12N 110

Patent

active

045900728

ABSTRACT:
A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slow-growing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.

REFERENCES:
Wright, et al. (1981), J. Protozool. 28 (1): 118-120.
Callow (1977), Adv. Exp. Med. Biol., 93: 121-149.
Erp, et al., 1978, Am. J. Trop. Med. Hyg. 27:1061-1064.
Levy et al., 1981, Cultivation of Babesia, pp. 207-223, in Ristic and Kreier, Babesiosis, Academic Press, Inc., N.Y.
Scheibel et al., 1979, Exp. Parasitol, 47:410-418.
Levy and Ristic (1980) Science 207: 1218-1220.
Smith, et al. (1979) Am. J. Vet. Res., vol. 40, No. 12: 1678-1682.
Smith et al. (1981) Science 212: 335-338.
Kuttler (1982) Am. J. Vet. Res. 43 (2): 281-284.
Callow, et al. (1979) Int. J. Parasitol 9: 333-338.

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