Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1986-02-25
1988-08-09
Hazel, Blondel
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 88, 435258, A61K 39018, C12N 110
Patent
active
047627115
ABSTRACT:
A live vaccine for bovine babesiosis comprises viable bovine erythrocytes parasitized with a cloned population of Babesia bovis, the clone strain being fast-growing, avirulent, and producing a mild but immunizing infection when administered. The vaccine is free of slow-growing virulent B. bovis. The clone strain used in the vaccine is prepared from a natural mixture of virulent and avirulent babesia by progressive dilution culturing to obtain cultures containing single parasites, propagating the single parasites under favorable conditions for growth, and selecting a fast-growing avirulent clone line for either in vitro or in vivo propagation to prepare the vaccines.
REFERENCES:
Wright et al., J. Protozool., vol. 28(1), pp. 118-120, 1981.
Callow, Adv. Exp. Med. Biol., vol. 93, pp. 121-149, 1977.
Callow et al., Int. J. Parasitol, vol. 9, pp. 333-338, 1979.
Levy and Ristic, Science, vol. 207, pp. 1218-1220, 1980.
Smith et al, Am. J. Vet. Res., vol. 40, pp. 1678-1682, 1979.
Smith et al., Science, vol. 212, pp. 335-338, 1981.
Kuttler, Am. J. Vet. Res., vol. 43, pp. 281-284, 1982.
Levy et al., Cultivation of Babesia, pp. 207-223, In Ristic and Kreier, Babesiosis, Academic Press, Inc, N.Y., 1981.
Erp et al., Am. J. Trop. Med. Ayg., vol. 27, pp. 1061-1064, 1978.
Scheibel et al., Exp. Parasitol., vol. 47, pp. 410-418, 1979.
Buening Gerald M.
Carson Charles A.
Hazel Blondel
The Curators of the University of Missouri
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